Salarieh Afshin, Rao Chandrakant, Gottesman Susan Rs, Alagha Osama, Todor Roxanne, Axiotis Constantine A
Department of Pathology, State University of New York-Downstate Medical Center, and Kings County Hospital Center, Brooklyn, NY 11203, USA.
Leuk Lymphoma. 2005 Jul;46(7):1067-74. doi: 10.1080/10428190500054566.
Plasma cell tumors show an increased incidence in HIV-positive patients. The cases reported in the literature suggest that plasma cell tumors occur in a younger age group than that encountered in the general population. Pathologically, many of these tumors show a plasmablastic morphology. Plasma cell tumors in HIV-positive patients may present at unusual sites and progress rapidly to involve multiple sites, including the soft tissues and viscera. The prognosis is generally poor. These features may be related to a combination of factors, including immunodeficiency, oncogenic viruses, and altered cytokine milieu in these patients. A case of plasma cell tumor in an HIV-positive patient is presented.
浆细胞瘤在HIV阳性患者中的发病率有所增加。文献报道的病例表明，浆细胞瘤的发病年龄比普通人群更年轻。病理上，许多此类肿瘤表现为浆母细胞形态。HIV阳性患者的浆细胞瘤可能出现在不寻常的部位，并迅速进展至累及多个部位，包括软组织和内脏。总体预后较差。这些特征可能与多种因素有关，包括免疫缺陷、致癌病毒以及这些患者体内细胞因子环境的改变。本文报告一例HIV阳性患者的浆细胞瘤病例。
