• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
APOE polymorphism, socioeconomic status and cognitive function in mid-life--the Whitehall II longitudinal study.载脂蛋白E基因多态性、社会经济地位与中年认知功能——白厅II纵向研究
Soc Psychiatry Psychiatr Epidemiol. 2005 Jul;40(7):557-63. doi: 10.1007/s00127-005-0925-y. Epub 2005 Jul 15.
2
The association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study.载脂蛋白 E ɛ4 与成人认知功能的关联及其与痴呆症发病的关系：Whitehall II 研究 20 年随访。
Alzheimers Res Ther. 2021 Jan 4;13(1):5. doi: 10.1186/s13195-020-00740-0.
3
Apolipoprotein E genotype and lifetime cognitive decline.载脂蛋白E基因型与终生认知能力衰退
Int Psychogeriatr. 2008 Feb;20(1):109-23. doi: 10.1017/S104161020700587X. Epub 2007 Aug 22.
4
APOE-epsilon4 is associated with memory decline in cognitively impaired elderly.载脂蛋白E-ε4与认知受损老年人的记忆力衰退有关。
Neurology. 2000 Apr 11;54(7):1492-7. doi: 10.1212/wnl.54.7.1492.
5
APOE genotype, memory test performance, and the risk of Alzheimer's disease in the Canadian Study of Health and Aging.加拿大健康与老龄化研究中的载脂蛋白E基因分型、记忆测试表现与阿尔茨海默病风险
Dement Geriatr Cogn Disord. 2003;15(1):1-5. doi: 10.1159/000066670.
6
Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairment.载脂蛋白E基因分型对轻度认知障碍门诊患者阿尔茨海默病的预测效用
Arch Neurol. 2005 Jun;62(6):975-80. doi: 10.1001/archneur.62.6.975.
7
Alzheimer's disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals.阿尔茨海默病遗传风险与认知储备与认知正常个体长期认知轨迹的关系。
Alzheimers Res Ther. 2023 Mar 28;15(1):66. doi: 10.1186/s13195-023-01206-9.
8
Stroke and apolipoprotein E epsilon4 are independent risk factors for cognitive decline: A population-based study.中风和载脂蛋白Eε4是认知功能衰退的独立危险因素：一项基于人群的研究。
Stroke. 2000 Oct;31(10):2431-6. doi: 10.1161/01.str.31.10.2431.
9
The relationship of APOE genotype to cognitive functioning in older African-American and Caucasian community residents.APOE基因分型与老年非裔美国人和白人社区居民认知功能的关系。
J Am Geriatr Soc. 2001 Sep;49(9):1148-55. doi: 10.1046/j.1532-5415.2001.49230.x.
10
Cognitive impairment in Alzheimer's disease is modified by APOE genotype.阿尔茨海默病中的认知障碍会因载脂蛋白E（APOE）基因型而改变。
Dement Geriatr Cogn Disord. 2007;24(2):98-103. doi: 10.1159/000104467. Epub 2007 Jun 26.

引用本文的文献

1
Paradoxical cognitive trajectories in men from earlier to later adulthood.男性从早期到后期成年期认知轨迹的矛盾变化。
Neurobiol Aging. 2022 Jan;109:229-238. doi: 10.1016/j.neurobiolaging.2021.10.002. Epub 2021 Oct 14.
2
Long-Term Levels of LDL-C and Cognitive Function: The CARDIA Study.长期 LDL-C 水平与认知功能：CARDIA 研究。
J Int Neuropsychol Soc. 2021 Nov;27(10):1048-1057. doi: 10.1017/S1355617721000059. Epub 2021 Feb 10.
3
APOE ε4 Modifies Effect of Residential Greenness on Cognitive Function among Older Adults: A Longitudinal Analysis in China.载脂蛋白 E ε4 修饰老年人居住绿化对认知功能的影响：中国的纵向分析。
Sci Rep. 2020 Jan 9;10(1):82. doi: 10.1038/s41598-019-57082-7.
4
The effect of life course socioeconomic position on crystallised cognitive ability in two large UK cohort studies: a structured modelling approach.英国两项大型队列研究中生命历程社会经济地位对晶体认知能力的影响：一种结构化建模方法。
BMJ Open. 2017 Jun 2;7(5):e014461. doi: 10.1136/bmjopen-2016-014461.
5
Associations between APOE and low-density lipoprotein cholesterol genotypes and cognitive and physical capability: the HALCyon programme.APOE与低密度脂蛋白胆固醇基因型和认知及身体能力之间的关联：HALCyon项目
Age (Dordr). 2014;36(4):9673. doi: 10.1007/s11357-014-9673-9. Epub 2014 Jul 30.
6
Maternal education, anthropometric markers of malnutrition and cognitive function (ELSA-Brasil).孕产妇教育、营养不良的人体测量指标与认知功能（巴西老年健康与衰老研究）
BMC Public Health. 2014 Jul 2;14:673. doi: 10.1186/1471-2458-14-673.
7
Socioeconomic inequality in domains of health: results from the World Health Surveys.健康领域的社会经济不平等：来自世界卫生调查的结果。
BMC Public Health. 2012 Mar 19;12:198. doi: 10.1186/1471-2458-12-198.
8
Presence of the APOE epsilon4 allele modifies the relationship between type 2 diabetes and cognitive performance: the Maine-Syracuse Study.载脂蛋白 E ɛ4 等位基因的存在改变了 2 型糖尿病与认知表现之间的关系：缅因州-锡拉丘兹研究。
Diabetologia. 2009 Dec;52(12):2551-60. doi: 10.1007/s00125-009-1497-2. Epub 2009 Aug 20.
9
Genetic and vascular modifiers of age-sensitive cognitive skills: effects of COMT, BDNF, ApoE, and hypertension.年龄敏感性认知技能的遗传和血管调节因素：儿茶酚-O-甲基转移酶、脑源性神经营养因子、载脂蛋白E及高血压的影响
Neuropsychology. 2009 Jan;23(1):105-116. doi: 10.1037/a0013487.
10
A procedure to correct proxy-reported weight in the National Health Interview Survey, 1976-2002.一种修正 1976-2002 年全国健康访谈调查中代理报告体重的方法。
Popul Health Metr. 2009 Jan 6;7:2. doi: 10.1186/1478-7954-7-2.

本文引用的文献

1
Gender differences in level and change in cognitive functioning. Results from the Longitudinal Aging Study Amsterdam.认知功能水平及变化中的性别差异。阿姆斯特丹纵向衰老研究结果
Gerontology. 2004 Jan-Feb;50(1):35-8. doi: 10.1159/000074387.
2
Leisure activities and cognitive function in middle age: evidence from the Whitehall II study.中年时期的休闲活动与认知功能：来自白厅II研究的证据。
J Epidemiol Community Health. 2003 Nov;57(11):907-13. doi: 10.1136/jech.57.11.907.
3
Lifetime antecedents of cognitive reserve.认知储备的终生前因。
J Clin Exp Neuropsychol. 2003 Aug;25(5):614-24. doi: 10.1076/jcen.25.5.614.14581.
4
Cognitive change and the APOE epsilon 4 allele.认知变化与载脂蛋白E ε4等位基因
Nature. 2002 Aug 29;418(6901):932. doi: 10.1038/418932a.
5
Change in cognitive functioning associated with apoE genotype in a community sample of older adults.老年人群社区样本中与载脂蛋白E基因型相关的认知功能变化。
Psychol Aging. 2002 Jun;17(2):194-208.
6
Longitudinal analysis of the effect of apolipoprotein E epsilon4 and education on cognitive performance in elderly subjects: the PAQUID study.载脂蛋白Eε4与教育程度对老年受试者认知能力影响的纵向分析：PAQUID研究
J Neurol Neurosurg Psychiatry. 2002 Jun;72(6):794-7. doi: 10.1136/jnnp.72.6.794.
7
Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults.载脂蛋白E基因型不能预测健康老年人的智力衰退。
Neurosci Lett. 2002 May 10;324(1):74-6. doi: 10.1016/s0304-3940(02)00135-0.
8
Apolipoprotein E gender effects on cognitive performance in age-associated memory impairment.载脂蛋白E性别差异对年龄相关性记忆障碍认知表现的影响。
J Neuropsychiatry Clin Neurosci. 2002 Winter;14(1):80-3. doi: 10.1176/jnp.14.1.80.
9
Genetics of brain function and cognition.脑功能与认知的遗传学
Behav Genet. 2001 Nov;31(6):489-95. doi: 10.1023/a:1013360909048.
10
Socioeconomic position across the lifecourse and cognitive function in late middle age.整个生命历程中的社会经济地位与中老年时期的认知功能
J Gerontol B Psychol Sci Soc Sci. 2002 Jan;57(1):S43-51. doi: 10.1093/geronb/57.1.s43.

载脂蛋白E基因多态性、社会经济地位与中年认知功能——白厅II纵向研究

APOE polymorphism, socioeconomic status and cognitive function in mid-life--the Whitehall II longitudinal study.

作者信息

Zhao J H, Brunner E J, Kumari M, Singh-Manoux A, Hawe E, Talmud P J, Marmot M G, Humphries S E

机构信息

Dept. of Epidemiology and Public Health, International Centre for Health and Society, 1-19 Torrington Place, London WC1E 6BT, UK.

出版信息

Soc Psychiatry Psychiatr Epidemiol. 2005 Jul;40(7):557-63. doi: 10.1007/s00127-005-0925-y. Epub 2005 Jul 15.

DOI:10.1007/s00127-005-0925-y
PMID:16021346
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5063922/
Abstract

OBJECTIVE

The aim of this study was to investigate the association of the common apolipoprotein E gene (APOE) variants with cognitive function and cognitive decline in adult mid-life and explore the possibility that APOE genotype mediates the link between socioeconomic status (SES) and cognitive function.

METHODS

Data on cognitive function, as measured by five cognitive tests, together with APOE genotype were obtained in an occupational cohort (the Whitehall II study) of 6,004 participants aged 44-69 years (1997-1999). Cognitive change was examined in 2,717 participants who had cognitive function measured at baseline (1991-1993).

RESULTS

SES based on civil service employment grade was strongly related to cognitive function. There was no association between APOE genotype and employment grade. In women, participants with APOE-epsilon4 had a lower memory score (p<0.05), but the result was sensitive to data from a small number of individuals. A marginal cross-sectional difference in the semantic fluency score was found (p=0.07), and there was a relative decline at follow-up (p<0.001, net change=-1.19; 95% CI, -1.90 to -0.49) in those with APOE-epsilon4 genotypes.

CONCLUSIONS

APOE-epsilon4 has little influence on cognitive decline in mid-life, whereas SES is a strong determinant, although APOE genotype may emerge as an important factor in cognitive function in later life.

摘要

目的

本研究旨在调查常见载脂蛋白E基因（APOE）变异与成年中年人群认知功能及认知衰退之间的关联，并探讨APOE基因型是否介导社会经济地位（SES）与认知功能之间的联系。

方法

在一项针对6004名年龄在44 - 69岁（1997 - 1999年）参与者的职业队列研究（白厅II研究）中，获取了通过五项认知测试所测量的认知功能数据以及APOE基因型数据。对2717名在基线（1991 - 1993年）时进行过认知功能测量的参与者进行了认知变化检查。

结果

基于公务员职业等级的SES与认知功能密切相关。APOE基因型与职业等级之间无关联。在女性中，携带APOE-ε4的参与者记忆得分较低（p<0.05），但该结果对少数个体的数据较为敏感。在语义流畅性得分方面发现了边缘性的横断面差异（p = 0.07），并且携带APOE-ε4基因型的参与者在随访时出现了相对衰退（p<0.001，净变化=-1.19；95%CI，-1.90至-0.49）。

结论

APOE-ε4对中年认知衰退影响较小，而SES是一个强有力的决定因素，尽管APOE基因型可能在晚年认知功能中成为一个重要因素。