Firbank Michael J, O'Brien John T, Pakrasi Sanjeet, Pantoni Leonardo, Simoni Michela, Erkinjuntti Timo, Wallin Anders, Wahlund Lars-Olof, van Straaten Ilse, Inzitari Domenico
Institute for Ageing and Health, University of Newcastle upon Tyne, UK.
Int J Geriatr Psychiatry. 2005 Jul;20(7):674-9. doi: 10.1002/gps.1342.
White matter hyperintensities have been associated with the development of depression in older subjects, though the details of this relationship are not fully understood.
In a pan-European multicentre study of 629 older subjects, we examined the relationship between MRI white matter hyperintensities (WMH), depressive symptoms and self perceived health quality of life (QOL). WMH were rated using a three-point scale.
We found depressive symptoms as assessed by the geriatric depression 15-item scale to be associated with WMH rating (Spearman's rho 0.11, p = 0.008) and also with the Euro-QOL health score (Spearman's rho -0.5, p < 0.001). In a ordinal logistic regression model, QOL was found to strongly predict GDS score (p < 0.001) and severe vs mild WMH were associated with increased depression (p = 0.028). The relationship between history of severe depression and WMH score was examined, but there were no differences either between those with and without a history of severe depression, or those with an early vs late onset of depression.
The results suggest that WMH play a role in increasing depressive symptoms, even when perceived quality of life is controlled for as a possible mediating factor.
白质高信号与老年受试者抑郁症的发生有关，尽管这种关系的细节尚未完全了解。
在一项对629名老年受试者进行的泛欧洲多中心研究中，我们研究了MRI白质高信号（WMH）、抑郁症状与自我感知的健康生活质量（QOL）之间的关系。WMH使用三点量表进行评分。
我们发现，通过老年抑郁15项量表评估的抑郁症状与WMH评分相关（斯皮尔曼等级相关系数为0.11，p = 0.008），也与欧洲生活质量健康评分相关（斯皮尔曼等级相关系数为 -0.5，p < 0.001）。在有序逻辑回归模型中，发现QOL能强烈预测老年抑郁量表（GDS）评分（p < 0.001），且严重与轻度WMH与抑郁增加相关（p = 0.028）。我们研究了重度抑郁病史与WMH评分之间的关系，但有或无重度抑郁病史者之间，以及抑郁早发与晚发者之间均无差异。
结果表明，即使将感知生活质量作为可能的中介因素进行控制，WMH在增加抑郁症状方面仍起作用。
