Oppedal K, Aarsland D, Firbank M J, Sonnesyn H, Tysnes O B, O'Brien J T, Beyer M K
Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway ; Department of Electrical Engineering and Computer Science, University of Stavanger, Stavanger, Norway.
Dement Geriatr Cogn Dis Extra. 2012 Jan;2(1):481-95. doi: 10.1159/000343480. Epub 2012 Nov 9.
The objective of this study was to explore the load of white matter hyperintensities (WMH) in patients with Lewy body dementia (LBD) and compare to Alzheimer's disease (AD) and normal controls (NC).
Diagnosis of LBD and AD was made according to consensus criteria and cognitive tests were administered. MRI scans for 77 (61 AD and 16 LBD) patients and 37 healthy elderly control subjects were available for analysis. We segmented WMH from FLAIR images using an automatic thresholding technique and calculated the volume of WMH in several regions of the brain, using non-parametric tests to compare groups. Multivariate regression was applied.
There were no significant differences in WMH between AD and LBD. We found a significant correlation between total and frontal WMH and Mini-Mental State Examination (MMSE) and verbal fluency scores in the AD group, but not in the LBD group.
The WMH load in LBD was similar to that of AD. A correlation between WMH load and cognition was found in the AD group, but not in the LBD group, suggesting that vascular disease contributes to cognitive impairment in AD but not LBD.
本研究的目的是探讨路易体痴呆（LBD）患者的白质高信号（WMH）负荷，并与阿尔茨海默病（AD）和正常对照（NC）进行比较。
根据共识标准对LBD和AD进行诊断，并进行认知测试。对77例（61例AD和16例LBD）患者和37例健康老年对照者的MRI扫描进行分析。我们使用自动阈值技术从液体衰减反转恢复（FLAIR）图像中分割出WMH，并计算大脑几个区域的WMH体积，使用非参数检验比较各组。应用多变量回归分析。
AD和LBD之间的WMH无显著差异。我们发现AD组中总WMH和额叶WMH与简易精神状态检查表（MMSE）及语言流畅性得分之间存在显著相关性，而LBD组中未发现。
LBD中的WMH负荷与AD相似。AD组中发现WMH负荷与认知之间存在相关性，而LBD组中未发现，这表明血管疾病导致AD的认知障碍，但不导致LBD的认知障碍。
