Di Francesco P, Marini S, Pica F, Favalli C, Tubaro E, Garaci E
Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Italy.
Immunol Res. 1992;11(1):74-9. doi: 10.1007/BF02918610.
The effect of in vivo cocaine administration on in vitro mitogen-induced lymphokine production was examined. Splenocyte cultures from BALB/c mice treated with an acute (1 mg/kg) or daily cocaine administration (1 mg/kg/day for 7 consecutive days) were less responsive to induction of IFN-gamma, IL-2 and IL-4 production by mitogen stimuli. We also evaluated the humoral immune response to both a T-dependent (HEL) and a T-independent antigen (rHBcAg). It was found that cocaine inhibits T-dependent antibody production only. This inhibition was greatest when cocaine was given during immunization. The results suggest that T-cell-mediated responses may be more affected by cocaine use/abuse.
研究了体内给予可卡因对体外有丝分裂原诱导的淋巴因子产生的影响。用急性剂量（1毫克/千克）或每日给予可卡因（连续7天，1毫克/千克/天）处理的BALB/c小鼠的脾细胞培养物，对有丝分裂原刺激诱导的IFN-γ、IL-2和IL-4产生的反应性较低。我们还评估了对T细胞依赖性（HEL）和T细胞非依赖性抗原（rHBcAg）的体液免疫反应。发现可卡因仅抑制T细胞依赖性抗体的产生。当在免疫期间给予可卡因时，这种抑制作用最大。结果表明，T细胞介导的反应可能更容易受到可卡因使用/滥用的影响。
