Madankumar Rajeevi, Tsang James, Lesser Martin L, Kenigsberg Daniel, Brenner Steven
Obstetrics and Gynecology, Long Island Jewish Medical Center, Suite 1100, 270-05, 76th Avenue, New Hyde Park, NY 11040, USA.
J Assist Reprod Genet. 2005 Apr;22(4):155-9. doi: 10.1007/s10815-005-4912-8.
To determine the optimal time for administration of human chorionic gonadotropin in clomiphene citrate induced intrauterine insemination cycles.
A retrospective analysis of 171 consecutive cycles was performed. An increase in luteinizing hormone level >100% over the mean of the preceding two days was defined as luteinizing hormone surge. Human chorionic gonadotropin was given in preparation for intrauterine insemination based on the follicle size and estradiol level prior to surge in 85 cycles (Group A), with the spontaneous surge in 64 cycles (Group B) and not given in 22 cycles (Group C) due to high luteinizing hormone levels.
The overall pregnancy rate per cycle was 18.1% (31/171), 15.2% (Group A), 20.3% (Group B) and 22.7% (Group C), (p > 0.50).
Although there may be physiological reasons to propose that timing the human chorionic gonadotropin to the luteinizing hormone surge will improve the success rate, they were not demonstrated.
确定在枸橼酸氯米芬诱导的宫腔内人工授精周期中注射人绒毛膜促性腺激素的最佳时间。
对171个连续周期进行回顾性分析。促黄体生成素水平较前两日均值升高>100%被定义为促黄体生成素峰。85个周期（A组）根据卵泡大小和促黄体生成素峰出现前的雌二醇水平给予人绒毛膜促性腺激素以准备宫腔内人工授精，64个周期（B组）促黄体生成素自然峰出现时给予，22个周期（C组）因促黄体生成素水平高未给予。
每个周期的总体妊娠率为18.1%（31/171），A组为15.2%，B组为20.3%，C组为22.7%（p>0.50）。
尽管可能存在生理原因表明根据促黄体生成素峰的时间注射人绒毛膜促性腺激素会提高成功率，但并未得到证实。
