Atashpour Shekoufeh, Kargar Jahromi Hossein, Kargar Jahromi Zahra, Maleknasab Mozhgan
Research Center for Non-Communicable Disease, Jahrom University of Medical Sciences, Jahrom, Iran.
Department of Pharmacology, Jahrom University of Medical Sciences, Jahrom, Iran.
Int J Reprod Biomed. 2017 Sep;15(9):561-568.
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women which affect fertility. Clomiphene citrate is used as first-line treatment for this disorder, which is associated with some complications and therapeutic resistance.
In this research, we compare the effectiveness of ginger with clomiphene on sexual hormones such as Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), estrogen and progesterone in order to treat PCOS effectively with fewer side effects.
In this experimental study, 63 adult female rats (170-200 gr) were studied and divided randomly into 9 groups as control (not received any interventional substance for 60 and 89 days), sham (were given distilled water and ethyl alcohol intraperitoneally daily for 60 and 89 days), and 7 experimental groups receiving estradiol valerate (PCOS inducing agent, intramuscular) alone and with 100 mg/kg clomiphene or different doses of ginger extract (175 and 350 mg/kg) orally daily for 60 and 89 days. Sexual hormones were analyzed and compared in different groups.
Our results showed that in the PCOS-induced group, LH and estrogen concentration increased while progesterone and FSH concentration decreased remarkably (p<0.05) as compared to control group. Furthermore, in groups receiving clomiphene and ginger extract, we demonstrated significant (p<0.05) improvement in hormonal secretion as compared to the PCOS-induced group. Clomiphene, compared with the lower dose of ginger extract, had a better improving effect on balancing sexual hormones in PCOS. Moreover, ginger extract at higher doses has better effects in improving PCOS.
As the long-term administration of clomiphene citrate has some side effects, the use of ginger as a herbal medicine without any side effects at high doses can be an effective and good alternative in improving PCOS.
多囊卵巢综合征（PCOS）是女性中最常见的影响生育能力的内分泌紊乱疾病。枸橼酸氯米芬被用作该疾病的一线治疗药物，但它会引发一些并发症和治疗抵抗。
在本研究中，我们比较生姜与氯米芬对促黄体生成素（LH）、促卵泡生成素（FSH）、雌激素和孕激素等性激素的影响，以便更有效地治疗PCOS且副作用更少。
在这项实验研究中，对63只成年雌性大鼠（170 - 200克）进行了研究，并随机分为9组，即对照组（60天和89天未接受任何干预物质）、假手术组（60天和89天每天腹腔注射蒸馏水和乙醇），以及7个实验组，分别单独给予戊酸雌二醇（PCOS诱导剂，肌肉注射），并与100毫克/千克氯米芬或不同剂量的生姜提取物（175毫克/千克和350毫克/千克）联合使用，每天口服，持续60天和89天。对不同组的性激素进行分析和比较。
我们的结果显示，与对照组相比，PCOS诱导组中LH和雌激素浓度升高，而孕激素和FSH浓度显著降低（p<0.05）。此外，与PCOS诱导组相比，接受氯米芬和生姜提取物的组中激素分泌有显著改善（p<0.05）。与较低剂量的生姜提取物相比，氯米芬在平衡PCOS性激素方面具有更好的改善效果。此外，高剂量的生姜提取物在改善PCOS方面效果更好。
由于长期服用枸橼酸氯米芬有一些副作用，高剂量使用无任何副作用的草药生姜可成为改善PCOS的有效且良好的替代方法。
