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大麻素在多发性硬化症中的应用。

The use of cannabinoids in multiple sclerosis.

作者信息

Teare Lara, Zajicek John

机构信息

Neurology Research Group, Peninsula Medical School, Plymouth PL6 8BX, UK.

出版信息

Expert Opin Investig Drugs. 2005 Jul;14(7):859-69. doi: 10.1517/13543784.14.7.859.

Abstract

Naturally occurring cannabinoids including Delta9-tetrahydrocannabinol and cannabidiol as well as endocannabinoids and synthetic cannabinoids may have a role in modulating experimental models of multiple sclerosis. Recent clinical studies to treat symptoms of multiple sclerosis have shown varying results, which may reflect issues relating to the way in which such studies were conducted. There is now increasing interest in the potential role of cannabinoids not only in symptom relief, but also for their possible neuroprotective actions.

摘要

天然存在的大麻素,包括Δ9-四氢大麻酚和大麻二酚,以及内源性大麻素和合成大麻素,可能在调节多发性硬化症的实验模型中发挥作用。最近治疗多发性硬化症症状的临床研究结果各异,这可能反映出与这些研究开展方式相关的问题。现在,人们越来越关注大麻素不仅在缓解症状方面的潜在作用,还关注其可能的神经保护作用。

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