Gouwy Mieke, Struyf Sofie, Proost Paul, Van Damme Jo
Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
Cytokine Growth Factor Rev. 2005 Dec;16(6):561-80. doi: 10.1016/j.cytogfr.2005.03.005. Epub 2005 Jul 14.
The inflammatory response is a highly co-ordinated process involving multiple factors acting in a complex network as stimulators or inhibitors. Upon infection, the sequential release of exogenous agents (e.g. bacterial and viral products) and induction of endogenous mediators (e.g. cytokines and chemokines) contribute to the recruitment of circulating leukocytes to the inflamed tissue. Microbial products trigger multiple cell types to release cytokines, which in turn are potent inducers of chemokines. Primary cytokines act as endogenous activators of the immune response, whereas inducible chemokines act as secondary mediators to attract leukocytes. Interaction between exogenous and endogenous mediators thus enhances the inflammatory response. In this review, the synergistic interaction between cytokines to induce chemokine production and the molecular mechanisms of the cooperation amongst co-induced chemokines to further increase leukocyte recruitment to the site of inflammation are discussed.
炎症反应是一个高度协调的过程，涉及多种因素在复杂网络中作为刺激物或抑制剂发挥作用。感染后，外源性物质（如细菌和病毒产物）的相继释放以及内源性介质（如细胞因子和趋化因子）的诱导，有助于将循环白细胞募集到炎症组织。微生物产物触发多种细胞类型释放细胞因子，而细胞因子反过来又是趋化因子的强效诱导剂。主要细胞因子作为免疫反应的内源性激活剂，而诱导性趋化因子作为吸引白细胞的次要介质。外源性和内源性介质之间的相互作用因此增强了炎症反应。在本综述中，讨论了细胞因子之间协同诱导趋化因子产生的相互作用以及共同诱导的趋化因子之间进一步增加白细胞募集到炎症部位的合作分子机制。
