Clunas Nathan J, Ward Philip B
Schizophrenia Research Unit, Level 1, Don Everett Building, Liverpool Hospital, South Western Sydney Area Health Service, Locked Bag 7103, Liverpool, BC, NSW 1871, Australia.
Psychiatry Res. 2005 Jul 15;136(1):17-25. doi: 10.1016/j.psychres.2005.05.009.
Previous event-related potential (ERP) studies reported evidence of impaired auditory information processing in patients with schizophrenia. The recovery cycle of the auditory N1 ERP component was measured in 17 patients with schizophrenia and 17 age- and sex-matched healthy volunteers. Subjects performed a visual distraction task while listening to 80-dB SPL, 1000-Hz tone pairs, presented with intra-pair intervals of 1, 3, 5 or 7 s, with inter-pair intervals of 9-13 s. Patients with schizophrenia had significantly reduced N1 amplitudes for S1 stimuli compared with healthy volunteers. For N1 amplitudes elicited by S2 stimuli, there was a significant group effect whilst the main effect of intra-pair interval was not significant. These results provide additional evidence of inhibitory auditory processing deficits in schizophrenia.
