Todd Juanita
Centre for Clinical Research in Neuropsychiatry, School of Psychiatry and Behavioural Science, University of Western Australia, Crawley, Western Australia, Australia.
Neuroreport. 2006 May 29;17(8):785-9. doi: 10.1097/01.wnr.0000220126.93973.31.
The reliably observed reduction in the mismatch negativity response to a change in sound duration in schizophrenia patients may be related to more widespread temporal processing impairments associated with the disorder. This study explored whether individuals with schizophrenia would show electrophysiological evidence of automatic deficits in the ability to detect changes in a regularly repeating interval between two tones. The established pattern was a repeating sequence of a pair of 50-ms tones with a 50-ms silent interval between them. In 8% of pairs, the silent interval between tones was increased to 125 ms. Significant differences in the response to the deviant tone pair in the patient group were consistent with impaired representation of the temporal relationship between sounds.
在精神分裂症患者中，可靠观察到的对声音时长变化的失配负波反应降低，可能与该疾病相关的更广泛的时间加工障碍有关。本研究探讨了精神分裂症患者是否会表现出电生理证据，证明其在检测两个音调之间有规律重复间隔变化的能力上存在自动缺陷。既定模式是一对50毫秒音调的重复序列，它们之间有50毫秒的静音间隔。在8%的配对中，音调之间的静音间隔增加到125毫秒。患者组对异常音调配对的反应存在显著差异，这与声音之间时间关系的表征受损一致。
