Hoffmann Mikael, Hammar Mats, Kjellgren Karin I, Lindh-Astrand Lotta, Brynhildsen Jan
Division of Clinical Pharmacology, Department of Medicine and Care, Linköping University, SE-581 83 Linköping, Sweden.
Maturitas. 2005 Sep 16;52(1):11-7. doi: 10.1016/j.maturitas.2005.06.003.
To assess changes in women's attitudes towards risk and benefits of, and use of hormone treatment in the menopausal transition (HT) before and after Heart and Estrogen/Progestin Replacement Study (HERS) and the oestrogen and progestin trial of Women's Health Initiative (WHI).
Postal questionnaires to all women 53 and 54 years of age in a Swedish community in 1999 (n=1.760) and 2003 (n=1.733). Data on sales of HT were collected from the database of the National Corporation of Swedish Pharmacies.
The fraction of women reporting current use of HT fell from 40.5 to 25.3% (p<0.001, chi2-test) both by fewer women starting and more women discontinuing treatment. This corresponded to a decrease in dispensation of HT in Linköping and nationwide for the same age group. The fraction of women who had tried complementary treatment for climacteric discomfort, increased from 9.6 to 18.1% for natural remedies (p<0.001, chi2-test). Women perceived HT as more risky and less beneficial in 2003 as compared with 1999 (both p<0.001, chi2-test). The most frequent source of information about HT during the last year before the 2003 questionnaire were newspaper or magazines (43.8%) and television or radio (31.7%).
The decreased use of HT in the community correlated with pronounced changes in the attitudes towards HT. Media were a more frequent source of information than health care personnel. This indicates that media reports about major clinical studies might have influenced the use of HT among women.
评估在心脏和雌激素/孕激素替代研究（HERS）以及妇女健康倡议（WHI）的雌激素和孕激素试验前后，处于绝经过渡期的女性对激素治疗（HT）的风险、益处及使用情况的态度变化。
于1999年（n = 1760）和2003年（n = 1733）向瑞典一个社区中所有53和54岁的女性邮寄调查问卷。从瑞典国家药房公司的数据库收集HT的销售数据。
报告当前正在使用HT的女性比例从40.5%降至25.3%（p<0.001，卡方检验），原因是开始治疗的女性减少且停止治疗的女性增多。这与林雪平及全国同年龄组HT配药量的减少相对应。尝试过针对更年期不适进行补充治疗的女性比例，天然疗法从9.6%增至18.1%（p<0.001，卡方检验）。与1999年相比，2003年女性认为HT风险更高且益处更少（均为p<0.001，卡方检验）。在2003年问卷调查前的最后一年，关于HT的最常见信息来源是报纸或杂志（43.8%）以及电视或广播（31.7%）。
社区中HT使用的减少与对HT态度的显著变化相关。媒体是比医护人员更常见的信息来源。这表明关于重大临床研究的媒体报道可能影响了女性对HT的使用。
