1998年至2003年间德国女性更年期激素疗法使用情况的差异。
Differences in menopausal hormone therapy use among women in Germany between 1998 and 2003.
作者信息
Du Yong, Dören Martina, Melchert Hans-Ulrich W, Scheidt-Nave Christa, Knopf Hildtraud
机构信息
Department of Epidemiology and Health Monitoring, Division of Non-Communicable Disease Epidemiology, Robert Koch-Institute, Berlin, Germany.
出版信息
BMC Womens Health. 2007 Oct 18;7:19. doi: 10.1186/1472-6874-7-19.
BACKGROUND
To examine the differences in menopausal hormone therapy (MHT) use and user profiles among women in Germany before and after the communication of the Women's Health Initiative (WHI) trial and other study results concerning the risks and benefits of MHT.
METHODS
Current MHT use was ascertained in two periodic German national health surveys conducted in 1997-1999 and 2003-2004. MHT prevalence and user profiles were assessed within each survey. The association of the survey period (2003-2004 vs. 1997-1999) with current MHT use was analyzed in weighted multivariable logistic regression (MLR) models, pooling data from both surveys.
RESULTS
The overall prevalence of current MHT use decreased by 40.2% from 16.9% of the sample in 1997-1999 to 10.1% in 2003-2004. The difference in prevalence between surveys varied with age decade with the smallest decreases among women 60-69 years of age (20.3% vs. 18.5%), compared to women of younger and older age groups (40-49: 10.7% vs. 3.9%; 50-59: 36.3% vs. 21.3%; 70-79: 5.7% vs. 3.2%). Variables independently associated with higher current MHT use in both health surveys included age category (curvilinear relationship with highest use among women 50-59 years) and residence in West vs. East Germany. A higher social status, lower body mass index, and more health-conscious behaviour were significantly associated with higher current MHT use in the 1997-1999 survey, but these associations were not found in the later survey. MLR analyses confirmed a significant decline in MHT use between the 1997-1999 and 2003-2004 surveys, however, the effect was modified by social status and was not significant among lowest social-status women.
CONCLUSION
Current MHT use considerably declined among women in Germany between the pre- and post-WHI era. A convergence of current MHT use among women of higher social status with pre-existing patterns of use among lower social-status women suggests that MHT in Germany is now less likely to be used for health promotion.
背景
考察在发布女性健康倡议(WHI)试验及其他有关绝经激素治疗(MHT)风险与益处的研究结果前后,德国女性在MHT使用情况及使用者特征方面的差异。
方法
在1997 - 1999年和2003 - 2004年进行的两次德国全国性定期健康调查中确定当前MHT的使用情况。在每次调查中评估MHT的患病率及使用者特征。在加权多变量逻辑回归(MLR)模型中分析调查时期(2003 - 2004年与1997 - 1999年)与当前MHT使用之间的关联,将两次调查的数据合并。
结果
当前MHT的总体使用率从1997 - 1999年样本的16.9%下降了40.2%,至2003 - 2004年的10.1%。两次调查之间的患病率差异随年龄组而变化,60 - 69岁女性的下降幅度最小(20.3%对18.5%),相比之下,年轻和年长年龄组的女性下降幅度较大(40 - 49岁:10.7%对3.9%;50 - 59岁:36.3%对21.3%;70 - 79岁:5.7%对3.2%)。在两次健康调查中,与当前较高MHT使用率独立相关的变量包括年龄类别(50 - 59岁女性使用率最高,呈曲线关系)以及居住在西德还是东德。较高的社会地位、较低的体重指数和更注重健康的行为在1997 - 1999年调查中与当前较高的MHT使用率显著相关,但在后来的调查中未发现这些关联。MLR分析证实,1997 - 1999年和2003 - 2004年调查之间MHT的使用显著下降,然而,这种影响因社会地位而有所改变,在社会地位最低的女性中不显著。
结论
在德国,WHI时代之前和之后,女性当前的MHT使用率大幅下降。社会地位较高的女性当前MHT使用情况与社会地位较低女性先前的使用模式趋同,这表明在德国,MHT现在用于促进健康的可能性较小。