Pedersen A, Hougen H P, Kenrad B
Department of Dentistry, National Hospital (Rigshospitalet), Copenhagen, Denmark.
J Oral Pathol Med. 1992 Apr;21(4):176-80. doi: 10.1111/j.1600-0714.1992.tb00097.x.
In the present study, the proportion of mononuclear cells and percentages of CD4+ (OKT4+) and CD8+ (OKT8+) were determined in clinically healthy buccal mucosa in patients with recurrent minor aphthous ulceration (RAU) (n = 43) during active and inactive disease as compared with RAU-free controls (n = 15). In lamina propria, the total number of mononuclear cells and subset percentages were determined histologically and immunohistochemically. Mononuclear cell counts in patient specimens were significantly lower than in the control group. CD4+ percentages were not significantly different between controls and patients. CD8+ percentages of the patients were significantly increased during active RAU, but not during inactive RAU as compared with controls. In proportion to the total number of mononuclear cells, CD4+ and CD8+ cell counts per 0.25 mm2 were significantly lower in the patients during both active and inactive disease as compared with controls. Thus, RAU seems characterized by reduced numbers of mononuclear cells, including T-lymphocytopenia in the oral mucosa as such, features that appear more pronounced during active disease than during quiescence.
在本研究中，对43例复发性轻型阿弗他溃疡（RAU）患者在疾病活动期和非活动期的临床健康颊黏膜中的单核细胞比例以及CD4 +（OKT4 +）和CD8 +（OKT8 +）百分比进行了测定，并与15例无RAU的对照者进行比较。在固有层中，通过组织学和免疫组织化学方法测定单核细胞总数和亚群百分比。患者标本中的单核细胞计数显著低于对照组。对照组和患者之间的CD4 +百分比无显著差异。与对照组相比，患者的CD8 +百分比在RAU活动期显著增加，但在非活动期无显著增加。与单核细胞总数成比例，每0.25 mm2的CD4 +和CD8 +细胞计数在患者的疾病活动期和非活动期均显著低于对照组。因此，RAU的特征似乎是单核细胞数量减少，包括口腔黏膜中的T淋巴细胞减少，这些特征在疾病活动期比静止期更为明显。
