Kaliamoorthy Sriram, Sathishmuthukumar Ramalingam, Chidambaram Keerthanasri, Srinivasan Paranthaman, Nagarajan Mahendirakumar, Selvakumar Rajkumar, Murugaboopathy Vikneshan
Department of Dentistry, Vinayaka Mission's Medical College, Vinayaka Mission's Research Foundation (Deemed To Be University), Karaikal, Puducherry, India.
Department of Oral and Maxillofacial Pathology, Chettinad Dental College and Research Institute, Tamil Nadu Dr. MGR Medical University, Kelambakkam, Tamil Nadu, India.
J Pharm Bioallied Sci. 2019 May;11(Suppl 2):S274-S277. doi: 10.4103/JPBS.JPBS_10_19.
Recurrent aphthous stomatitis represents one of the most common oral pathoses with multifactorial etiology. Decrease in mucosal barrier resistance is believed to be one of the etiologies in its pathogenesis. This study was conducted to assess the oral mucosal integrity status by evaluating the salivary albumin level in patients with aphthous stomatitis.
Thirty patients diagnosed with aphthous stomatitis were selected as case group. Equal number of age- and sex-matched healthy individuals formed the control group. Salivary albumin level was estimated during active and quiescent stage of the disease in both case group and control group.
Mean salivary albumin level for the case group during the active and quiescent stage was 0.070 g/dL (SD = 0.037) and 0.004 g/dL (SD = 0.007) (SPSS, version 7.0), respectively, and that for the control group was 0.027 g/dL (SD =0.042). Statistically significant difference was found on comparison of the mean salivary albumin level between the case group during active and quiescent stage and the normal controls using Mann-Whitney test. No statistically significant difference in salivary albumin level was seen between the quiescent stage in case group and the normal controls.
Increase in salivary albumin level at the time of disease presentation could be attributed to the leakage of albumin through the ulcerated mucosa. Absence of significant elevation in the salivary albumin level after the resolution of the aphthous ulcer apparently indicates inherently a healthy mucosal barrier in majority of the patients.
复发性阿弗他口炎是最常见的口腔疾病之一，病因多因素。黏膜屏障抵抗力降低被认为是其发病机制中的病因之一。本研究旨在通过评估阿弗他口炎患者唾液白蛋白水平来评估口腔黏膜完整性状态。
选取30例诊断为阿弗他口炎的患者作为病例组。年龄和性别匹配的健康个体数量相等，组成对照组。在病例组和对照组疾病的活动期和静止期均估计唾液白蛋白水平。
病例组活动期和静止期唾液白蛋白平均水平分别为0.070g/dL（标准差=0.037）和0.004g/dL（标准差=0.007）（SPSS，7.0版），对照组为0.027g/dL（标准差=0.042）。使用曼-惠特尼检验比较病例组活动期和静止期与正常对照组的唾液白蛋白平均水平，发现有统计学显著差异。病例组静止期与正常对照组唾液白蛋白水平无统计学显著差异。
疾病发作时唾液白蛋白水平升高可能归因于白蛋白通过溃疡黏膜渗漏。阿弗他溃疡愈合后唾液白蛋白水平无明显升高，显然表明大多数患者的黏膜屏障本质上是健康的。
