Chow Louis W C, Lui Ka Luen, Chan Johnny Chun Yin, Chan Tuen Ching, Ho Po Ki, Lee Wing Yi, Leung Lik Hang, Sy Wing Man, Yeung Chin Chin, Yung Amy Ka Man
Department of Surgery, University of Hong Kong, Hong Kong SAR, China.
Asian J Surg. 2005 Jul;28(3):179-84. doi: 10.1016/S1015-9584(09)60338-9.
To analyse the association between body mass index (BMI) and breast cancer risk among Chinese women in Hong Kong.
We conducted a population-based case control study of breast cancer in June 2002. Standardized questionnaires concerning BMI and other anthropometric data were completed by patients at the Queen Mary Hospital (QMH). The cases were 198 women aged 24-85 years who had documented breast cancer in 1995-2000 by triple assessment criteria, and the controls were 353 women who were followed up at QMH for benign breast disease after breast cancer had been excluded by triple assessment. The controls were frequency-matched to the cases by age.
BMI at diagnosis was positively correlated with the risk of breast cancer among postmenopausal women (p < 0.001 for trend). Also, when compared with women with a low BMI (< 19), women with a BMI of 23-27 and 27-31 had a 1.73-fold (95% confidence interval, CI, 1.04-2.86) and 2.06-fold (95% CI, 1.08-3.93) increased risk of breast cancer, respectively, after adjustment for non-anthropometric risk factors. BMI at diagnosis, however, was not related to the risk of breast cancer among premenopausal women. The odds ratios for premenopausal women with a BMI of 23-27 and 27-31 were 1.5 (95% CI, 0.82-2.71) and 1.32 (95% CI, 0.39-4.43), respectively. Furthermore, present BMI and BMI 5 years before diagnosis were poorly associated with breast cancer risk among both pre- and postmenopausal women.
Weight control in obese women may be an effective measure for breast cancer prevention in postmenopausal women.
分析香港中国女性的体重指数（BMI）与乳腺癌风险之间的关联。
2002年6月，我们开展了一项基于人群的乳腺癌病例对照研究。玛丽医院（QMH）的患者完成了关于BMI及其他人体测量数据的标准化问卷。病例为198名年龄在24 - 85岁之间的女性，她们在1995 - 2000年期间经三重评估标准确诊患有乳腺癌；对照为353名女性，她们在经三重评估排除乳腺癌后因良性乳腺疾病在QMH接受随访。对照按年龄与病例进行频数匹配。
绝经后女性诊断时的BMI与乳腺癌风险呈正相关（趋势p < 0.001）。此外，与BMI低（< 19）的女性相比，在调整非人体测量风险因素后，BMI为23 - 27和27 - 31的女性患乳腺癌的风险分别增加了1.73倍（95%置信区间，CI，1.04 - 2.86）和2.06倍（95% CI，1.08 - 3.93）。然而，诊断时的BMI与绝经前女性的乳腺癌风险无关。BMI为23 - 27和27 - 31的绝经前女性的优势比分别为1.5（95% CI，0.82 - 2.71）和1.32（95% CI，0.39 - 4.43）。此外，绝经前和绝经后女性当前的BMI以及诊断前5年的BMI与乳腺癌风险的关联都较弱。
控制肥胖女性的体重可能是绝经后女性预防乳腺癌的有效措施。
