Arase Yasuji, Ikeda Kenji, Suzuki Fumitaka, Suzuki Yoshiyuki, Saitoh Satoshi, Kobayashi Masahiro, Akuta Norio, Someya Takashi, Hosaka Tetsuya, Sezaki Hitomi, Kobayashi Mariko, Kumada Hiromitsu
Department of Gastroenterology and Hepatic Research Unit, Toranomon Hospital, Tokyo, Japan.
Intervirology. 2005;48(6):400-4. doi: 10.1159/000086067.
The aim of this study is to evaluate the serum level of KL-6 in hepatitis C virus (HCV)-positive patients with chronic liver disease.
Subjects consisted of 502 HCV-positive patients. The serum samples of these patients stored at -80 degrees C were measured by enzyme-linked immunosorbent assay for KL-6 at the same time. The cutoff point of the serum KL-6 level was defined as 500 U/ml. The serum KL-6 level of the 502 patients ranged between 71 and 2,295 (median, 223) U/ml. Thirty-two of the 502 (6.4%) patients showed an elevated KL-6 level of >500 U/ml. Three of the 32 (9.4%) patients with elevated KL-6 level >500 U/ml had idiopathic pulmonary fibrosis. Multivariate analysis showed that patients achieved elevated KL-6 when: (1) they had hepatocellular carcinoma (HCC; p = 0.0007), and (2) age was >60 years (p = 0.0085). The HCC rate was 37.5% (12/32) in the patients with elevated KL-6 and 8.3% (39/470) in the patients with normal KL-6 group. The median (range) age was 70 (56-77) years in the patients with elevated KL-6 group and 60 (12-92) years in the patients with normal KL-6.
The patients with HCC aged >60 years had significantly elevated serum levels of KL-6.
本研究旨在评估丙型肝炎病毒（HCV）阳性慢性肝病患者的血清KL-6水平。
研究对象为502例HCV阳性患者。同时采用酶联免疫吸附测定法检测这些储存在-80℃的患者血清样本中的KL-6。血清KL-6水平的临界值定义为500 U/ml。502例患者的血清KL-6水平在71至2295（中位数为223）U/ml之间。502例患者中有32例（6.4%）的KL-6水平升高>500 U/ml。32例KL-6水平>500 U/ml的患者中有3例（9.4%）患有特发性肺纤维化。多因素分析显示，患者出现KL-6水平升高的情况为：（1）患有肝细胞癌（HCC；p = 0.0007），以及（2）年龄>60岁（p = 0.0085）。KL-6水平升高的患者中HCC发生率为37.5%（12/32），KL-6水平正常组患者中HCC发生率为8.3%（39/470）。KL-6水平升高组患者的年龄中位数（范围）为70（56 - 77）岁，KL-6水平正常组患者的年龄中位数（范围）为60（12 - 92）岁。
年龄>60岁的HCC患者血清KL-6水平显著升高。
