Flanigan G D, Mayfield R, Blumenthal H T
Department of Community Medicine, St Louis University School of Medicine, MO 63104.
J Natl Med Assoc. 1992 Jan;84(1):23-7.
The second part of this study deals with blood lead (PbB) levels in 541 pregnant women and 351 nonpregnant women of childbearing age residing in the health center's catchment area. Each blood sample was analyzed for erythroprotoporphyrin (EP) and PbB. Comparisons of these data were made with national data on women of childbearing age and with children in our catchment area, as well as with children nationally. Mean PbB and prevalence rates at greater than or equal to 10 and greater than or equal to 15 micrograms/dL were higher in the nonpregnant women of the catchment area than in the pregnant women. For comparison with women nationally, the data on these two groups were combined because national data did not clearly distinguish between pregnant and nonpregnant women. The women in the catchment area showed mean PbB and prevalence rates at the two ranges noted above that were not only higher than in white women but also generally higher than in black women nationally. Thus, this rank order was similar to that reported earlier for children. The comparisons between women and children living in the same environment showed that the children have significantly higher mean PbBs and prevalence rates at the two ranges than the women. The physiological and environmental bases for these differences are discussed. As in the study on children, the EP is also not adequate as a screening procedure for identifying women with PbB levels greater than or equal to 25 and greater than or equal to 15 micrograms/dL.
本研究的第二部分涉及居住在该健康中心服务区域内的541名孕妇和351名育龄非孕妇的血铅(PbB)水平。对每份血样进行了红细胞原卟啉(EP)和PbB分析。将这些数据与全国育龄妇女数据、本服务区域内儿童数据以及全国儿童数据进行了比较。该服务区域内非孕妇的平均PbB水平以及大于或等于10微克/分升和大于或等于15微克/分升的患病率高于孕妇。为了与全国妇女进行比较,将这两组数据合并,因为全国数据未明确区分孕妇和非孕妇。该服务区域内的妇女在上述两个范围内的平均PbB水平和患病率不仅高于全国白人妇女,而且总体上也高于全国黑人妇女。因此,这种排序与先前报道的儿童情况相似。对生活在同一环境中的妇女和儿童进行比较发现,儿童在上述两个范围内的平均PbB水平和患病率显著高于妇女。文中讨论了这些差异的生理和环境基础。与儿童研究一样,EP也不足以作为筛查程序来识别PbB水平大于或等于25微克/分升和大于或等于15微克/分升的妇女。