脑部疾病中的耐药性及药物外排转运体的作用

Drug resistance in brain diseases and the role of drug efflux transporters.

作者信息

Löscher Wolfgang, Potschka Heidrun

机构信息

Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, and Center for Systems Neuroscience, Bünteweg 17, D-30559 Hannover, Germany.

出版信息

Nat Rev Neurosci. 2005 Aug;6(8):591-602. doi: 10.1038/nrn1728.

DOI:10.1038/nrn1728

PMID:16025095

Abstract

Resistance to drug treatment is an important hurdle in the therapy of many brain disorders, including brain cancer, epilepsy, schizophrenia, depression and infection of the brain with HIV. Consequently, there is a pressing need to develop new and more effective treatment strategies. Mechanisms of resistance that operate in cancer and infectious diseases might also be relevant in drug-resistant brain disorders. In particular, drug efflux transporters that are expressed at the blood-brain barrier limit the ability of many drugs to access the brain. There is increasing evidence that drug efflux transporters have an important role in drug-resistant brain disorders, and this information should allow more efficacious treatment strategies to be developed.

摘要

对药物治疗产生耐药性是许多脑部疾病治疗中的一个重要障碍，这些疾病包括脑癌、癫痫、精神分裂症、抑郁症以及脑部感染艾滋病毒。因此，迫切需要开发新的、更有效的治疗策略。在癌症和传染病中起作用的耐药机制可能在耐药性脑部疾病中也同样相关。特别是在血脑屏障表达的药物外排转运蛋白限制了许多药物进入大脑的能力。越来越多的证据表明，药物外排转运蛋白在耐药性脑部疾病中起重要作用，这些信息应有助于开发更有效的治疗策略。