Kirit Esen, Gokce Cemile, Altun Buse, Yilmazer Açelya
Department of Biomedical Engineering, Ankara University, Golbasi, Ankara 06830, Turkey.
Stem Cell Institute, Ankara University, Balgat, Ankara 06520, Turkey.
ACS Omega. 2025 Jul 24;10(30):32606-32625. doi: 10.1021/acsomega.5c02206. eCollection 2025 Aug 5.
The blood-brain barrier (BBB) is the main obstacle preventing access to the central nervous system (CNS). It is therefore a major challenge in CNS studies, e.g., investigations of novel therapeutic agents for brain tumors, such as glioblastoma multiforme (GBM). Ensuring the structural and functional integrity of the BBB is essential for such studies. Therefore, the BBB and blood-brain-tumor barrier (BBTB) behaviors must be further investigated to enhance the treatment effectiveness in neurodegenerative diseases (NDDs). Researchers are striving to use nanoparticles (NPs) and/or develop nano delivery systems (NDSs) to efficiently overcome the barriers to transporting neurotherapeutics to the brain, focusing on targeting disease or tumor sites. In this regard, BBB disease modeling enables examination of the transport of these molecules and/or systems from the bloodstream to the brain. Facilitating their transport is likely to enhance their investigation in CNS studies and potentially lead to their use in treating various NDDs. This review describes the BBB, NPs, and/or NDSs used in BBB studies and evaluates the ability of existing BBB disease models to precisely forecast the in vivo efficacy of NPs or NDSs.
血脑屏障（BBB）是阻碍进入中枢神经系统（CNS）的主要障碍。因此，它是中枢神经系统研究中的一项重大挑战，例如对脑肿瘤新型治疗药物的研究，如多形性胶质母细胞瘤（GBM）。确保血脑屏障的结构和功能完整性对于此类研究至关重要。因此，必须进一步研究血脑屏障和血脑肿瘤屏障（BBTB）的行为，以提高神经退行性疾病（NDDs）的治疗效果。研究人员正在努力使用纳米颗粒（NPs）和/或开发纳米递送系统（NDSs），以有效地克服将神经治疗药物输送到大脑的障碍，重点是靶向疾病或肿瘤部位。在这方面，血脑屏障疾病建模能够检查这些分子和/或系统从血液到大脑的转运。促进它们的转运可能会加强它们在中枢神经系统研究中的研究，并有可能导致它们用于治疗各种神经退行性疾病。本综述描述了血脑屏障研究中使用的血脑屏障、纳米颗粒和/或纳米递送系统，并评估了现有血脑屏障疾病模型精确预测纳米颗粒或纳米递送系统体内疗效的能力。
