Lei Kelu, Zhou Lanyu, Dan Min, Yang Fei, Jian Tiantian, Xin Juan, Yu Zhigang, Wang Yue
Department of Pharmacy, Ya'an People's Hospital-West China Ya'an Hospital, Sichuan University, Ya'an 625000, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Pharmaceutics. 2025 Feb 20;17(3):280. doi: 10.3390/pharmaceutics17030280.
Central nervous system (CNS) diseases, such as brain tumors, Alzheimer's disease, and Parkinson's disease, significantly impact patients' quality of life and impose substantial economic burdens on society. The blood-brain barrier (BBB) limits the effective delivery of most therapeutic drugs, especially natural products, despite their potential therapeutic effects. The Trojan Horse strategy, using nanotechnology to disguise drugs as "cargo", enables them to bypass the BBB, enhancing targeting and therapeutic efficacy. This review explores the applications of natural products in the treatment of CNS diseases, discusses the challenges posed by the BBB, and analyzes the advantages and limitations of the Trojan Horse strategy. Despite the existing technical challenges, future research is expected to enhance the application of natural drugs in CNS treatment by integrating nanotechnology, improving delivery mechanisms, and optimizing targeting characteristics.
中枢神经系统（CNS）疾病，如脑肿瘤、阿尔茨海默病和帕金森病，严重影响患者的生活质量，并给社会带来巨大的经济负担。血脑屏障（BBB）限制了大多数治疗药物，尤其是天然产物的有效递送，尽管它们具有潜在的治疗效果。“特洛伊木马”策略利用纳米技术将药物伪装成“货物”，使其能够绕过血脑屏障，提高靶向性和治疗效果。本综述探讨了天然产物在中枢神经系统疾病治疗中的应用，讨论了血脑屏障带来的挑战，并分析了“特洛伊木马”策略的优缺点。尽管存在现有的技术挑战，但未来的研究有望通过整合纳米技术、改进递送机制和优化靶向特性，加强天然药物在中枢神经系统治疗中的应用。
