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某些乙酰胆碱酯酶复活剂对沙林和环沙林诱导抑制的体外复活效力。

In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions.

作者信息

Kuca Kamil, Cabal Jiri, Jun Daniel, Kassa Jiri, Bartosová Lucie, Kunesová Gabriela

机构信息

Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic.

出版信息

J Appl Toxicol. 2005 Jul-Aug;25(4):296-300. doi: 10.1002/jat.1065.

DOI:10.1002/jat.1065
PMID:16025528
Abstract

In our study, we have tested six acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, HI-6, trimedoxime, BI-6 and Hlö-7) for reactivation of sarin- and cyclosarin-inhibited AChE using an in vitro reactivation test. We have used rat brain homogenate as the suitable source of enzyme. All oximes are able to reactivate sarin-inhibited AChE. On the other hand, only HI-6 is able to reactivate satisfactorily cyclosarin-inhibited AChE.

摘要

在我们的研究中，我们使用体外再活化试验测试了六种乙酰胆碱酯酶（AChE）复活剂（解磷定、双复磷、HI-6、氯磷定、BI-6和Hlö-7）对沙林和环沙林抑制的AChE的再活化作用。我们使用大鼠脑匀浆作为合适的酶源。所有肟类化合物都能够使沙林抑制的AChE再活化。另一方面，只有HI-6能够令人满意地使环沙林抑制的AChE再活化。

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