Kuca Kamil, Cabal Jiri, Jun Daniel, Kassa Jiri, Bartosová Lucie, Kunesová Gabriela
Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic.
J Appl Toxicol. 2005 Jul-Aug;25(4):296-300. doi: 10.1002/jat.1065.
In our study, we have tested six acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, HI-6, trimedoxime, BI-6 and Hlö-7) for reactivation of sarin- and cyclosarin-inhibited AChE using an in vitro reactivation test. We have used rat brain homogenate as the suitable source of enzyme. All oximes are able to reactivate sarin-inhibited AChE. On the other hand, only HI-6 is able to reactivate satisfactorily cyclosarin-inhibited AChE.
在我们的研究中，我们使用体外再活化试验测试了六种乙酰胆碱酯酶（AChE）复活剂（解磷定、双复磷、HI-6、氯磷定、BI-6和Hlö-7）对沙林和环沙林抑制的AChE的再活化作用。我们使用大鼠脑匀浆作为合适的酶源。所有肟类化合物都能够使沙林抑制的AChE再活化。另一方面，只有HI-6能够令人满意地使环沙林抑制的AChE再活化。
