Colin J F, Elliot P, Ellis H
Br J Surg. 1979 Nov;66(11):793-7. doi: 10.1002/bjs.1800661113.
Acute uraemia was induced in rats by performing a 70 per cent nephrectomy. Uraemia was shown to delay the healing of intestinal anastomoses and abdominal wounds in rats as judged by bursting strength tests. Cellular proliferation was depressed at wound edges but there was no reduction in the total amount of hydroxyproline present in the wounds. Fibroblast growth in tissue culture was affected by the addition both of uraemic plasma and of urea solution to the culture medium. The possible causes of these effects are discussed.
通过切除70%的肾组织在大鼠中诱发急性尿毒症。通过破裂强度测试判断，尿毒症会延迟大鼠肠吻合口和腹部伤口的愈合。伤口边缘的细胞增殖受到抑制，但伤口中羟脯氨酸的总量没有减少。在组织培养中，向培养基中添加尿毒症血浆和尿素溶液均会影响成纤维细胞的生长。本文讨论了这些影响的可能原因。
