Yin Yan-ru, Bai Lin, Wang Fei
Department of Physiology, Southern Medical University, Guangzhou 510515, China.
Di Yi Jun Yi Da Xue Xue Bao. 2005 Jul;25(7):766-8.
To study the effect of L-arginine (L-arg) on the sebaceous gland of SD rat.
The SD rats of different sexes and ages were subjected to intragastric administration of L-arg at 10 mg.kg(-1).d(-1) (L-arg group) or saline (saline group) for 14 days. Blood samples were obtained from these rats for serum androgen determination and the pathological changes of the skin were observed.
After L-arg treatment for 7 days, the dorsal hair of all the adult male rats appeared damp, greasy and yellow, while that of the adult and 5-week-old female rats looked normal. When the treatment was prolonged to 14 days, the same changes occurred in most of the adult female rats and all the 5-week-old female rats. The sebaceous glands of the abnormal skin showed hyperplasia in pathologic examination. The serum levels of androgen in rats with sebaceous gland hyperplasia were significantly higher than those in the control rats.
L-arg can promote sebaceous gland hyperplasia in rats in relation to increased androgen secretion induced by L-arg and NO.
研究L-精氨酸（L-arg）对SD大鼠皮脂腺的影响。
对不同性别和年龄的SD大鼠分别灌胃给予10 mg.kg(-1).d(-1)的L-精氨酸（L-arg组）或生理盐水（生理盐水组），持续14天。采集这些大鼠的血样用于测定血清雄激素，并观察皮肤的病理变化。
L-arg治疗7天后，所有成年雄性大鼠的背部毛发变得潮湿、油腻且发黄，而成年雌性大鼠和5周龄雌性大鼠的毛发外观正常。当治疗延长至14天时，大多数成年雌性大鼠和所有5周龄雌性大鼠都出现了相同的变化。病理检查显示，异常皮肤的皮脂腺增生。皮脂腺增生大鼠的血清雄激素水平显著高于对照大鼠。
L-arg可促进大鼠皮脂腺增生，这与L-arg和一氧化氮诱导的雄激素分泌增加有关。
