Abramovici A, Wolf R, Sandbank M
Acta Derm Venereol. 1983;63(5):428-31.
The long-lasting effect of a flavour cosmetic constituent on male rat skin was studied. Topical daily application of citral (15.4%) solution for 3 months produced an increase in the number of sebaceous gland lobules and hyperplasia of sebaceous cells in each gland. It is suggested that the mechanism of this hyperplasia might be activation of the testosterone 5 alpha-reductase which induces the formation of dihydrotestosterone, the mediator of sebaceous gland activity.
研究了一种香料化妆品成分对雄性大鼠皮肤的长期影响。每天局部涂抹柠檬醛（15.4%）溶液，持续3个月，可使皮脂腺小叶数量增加，且每个腺体中的皮脂腺细胞增生。有人认为，这种增生的机制可能是睾酮5α-还原酶的激活，该酶可诱导二氢睾酮的形成，而二氢睾酮是皮脂腺活动的介质。
