Gutin Bernard, Harris Ryan A, Howe Cheryl A, Johnson Maribeth H, Zhu Haidong, Dong Yanbin
Georgia Prevention Institute, Department of Pediatrics, Georgia Health Sciences University (Formerly the Medical College of Georgia), Augusta, GA 30912, USA.
Int J Pediatr. 2011;2011:219268. doi: 10.1155/2011/219268. Epub 2011 Oct 11.
There is little evidence from randomized trials showing that physical activity alone influences biomarker profiles in youths. This study tested two hypotheses: (i) that elevated body fatness and poor fitness would be associated with unfavorable levels of cardiometabolic biomarkers in 8-12-y-old black girls (n = 242) and (ii) that a 10-mo PA intervention would have favorable effects on the fatness-related cardiometabolic biomarkers. At baseline, all fatness indices (i.e., percent body fat, visceral adipose tissue, BMI, and waist circumference) were significantly (P < 0.05) associated with unfavorable levels of insulin, glucose, systolic BP, diastolic BP, triglycerides, C-reactive protein (CRP), and fibrinogen. Aerobic fitness was significantly (P < 0.05) associated with favorable levels of insulin, CRP, fibrinogen, and HDL(2). The PA intervention had significant and favorable effects on fitness, fatness, and two biomarkers-resting heart rate and LDL cholesterol. More research is needed to clarify what types of interventions can enhance the cardiometabolic health of youths.
随机试验几乎没有证据表明，仅体育活动就能影响青少年的生物标志物水平。本研究检验了两个假设：（i）体脂增加和健康状况不佳与8至12岁黑人女孩（n = 242）中心血管代谢生物标志物的不良水平相关；（ii）为期10个月的体育活动干预将对与肥胖相关的心血管代谢生物标志物产生有益影响。在基线时，所有肥胖指数（即体脂百分比、内脏脂肪组织、体重指数和腰围）均与胰岛素、葡萄糖、收缩压、舒张压、甘油三酯、C反应蛋白（CRP）和纤维蛋白原的不良水平显著相关（P < 0.05）。有氧适能与胰岛素、CRP、纤维蛋白原和高密度脂蛋白2（HDL(2)）的良好水平显著相关（P < 0.05）。体育活动干预对适能、肥胖以及两个生物标志物——静息心率和低密度脂蛋白胆固醇产生了显著且有益的影响。需要更多研究来阐明何种类型的干预措施能够增强青少年的心血管代谢健康。
