Marquart Karl-Horst
Institute of Molecular Virology, GSF National Research Center for Environment and Health, Neuherberg, Germany.
Ultrastruct Pathol. 2005 Mar-Apr;29(2):85-93. doi: 10.1080/01913120590912205.
Biopsied tissue specimens from 40 cases of classic, atypical classic, endemic, and AIDS-associated Kaposi's sarcoma (KS) were investigated by electron microscopy. To search for ultrastructural differences between non-AIDS-associated KS and AIDS-associated KS, the occurrence of the following 2 ultrastructural abnormalities of the rough-surfaced endoplasmic reticulum in KS cells was evaluated semi-quantitatively: tubuloreticular structures (TRS) and intracisternal paracrystalline inclusions (IPI). These peculiar structures were found in 23 of the 40 KS cases. Two types of TRS could be distinguished: loose TRS (LTRS) and compact ones (CTRS). LTRS were observed in endothelial cells of tissue from all the different epidemiological types of KS. CTRS were confined to AIDS-associated KS. IPI were present in endothelial tumor cells of only 3 non-AIDS-associated KS cases. The study shows that in cells of KS tissue only CTRS, but not LTRS, are an ultrastructural marker for AIDS-associated KS.
对40例经典型、非典型经典型、地方性和艾滋病相关的卡波西肉瘤（KS）的活检组织标本进行了电子显微镜检查。为了寻找非艾滋病相关KS与艾滋病相关KS之间的超微结构差异，对KS细胞中粗面内质网的以下2种超微结构异常的出现情况进行了半定量评估：管状网状结构（TRS）和池内副结晶包涵体（IPI）。在40例KS病例中的23例发现了这些特殊结构。可区分出两种类型的TRS：松散型TRS（LTRS）和致密型TRS（CTRS）。在所有不同流行病学类型KS组织的内皮细胞中均观察到LTRS。CTRS仅限于艾滋病相关KS。IPI仅存在于3例非艾滋病相关KS病例的内皮肿瘤细胞中。该研究表明，在KS组织细胞中，只有CTRS而非LTRS是艾滋病相关KS的超微结构标志物。
