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[塔希提岛高尿酸血症研究。在帕皮提(塔希提岛)地区医院中心住院的31例患者]

[Study of hyperuricemia in Tahiti. 31 cases hospitalized at the Territorial Hospital Center in Papeete (Tahiti)].

作者信息

Prigent D, Spiegel A, Brodin S, Gras C

机构信息

Médecin des Hôpitaux des Armées Centre Hospitalier Territorial, Papeete, Tahiti, Polynésie Française.

出版信息

Med Trop (Mars). 1992 Jan-Mar;52(1):63-6.

PMID:1602955
Abstract

Frequency of gout in French Polynesia has induced us to define a type of "hyperuricemia Polynesian" from a population of patients admitted in a general Medicine Ward. Each admitted patient gets immediately a blood check-up. A figure higher than 70 mg/l in male and 60 mg/l in female is considered as pathological. In such a case, uricemia and uraturia are tested every 24 h for three days and we consider the mean value of these three tests. On the other side, some admitted patients non-hyperuricemic, are examined according to the same protocol. So, we have two groups: 31 hyperuricemics and 20 non-hyperuricemics, secondarily grouped according to age, sex, ethnic. We did not consider some secondary causes of hyperuricemia (chronic renal insufficiency diuretic treatment, psoriasis etc.). 1. Within the hyperuricemic population, mean uricemia is 85.35 mg/l versus 52.65 mg/l in the second sample. In the hyperuricemic group (21 males and 10 females) 48% are gouty and 13% of them are females. Articular manifestations are acute arthritis, affecting mainly inferior limbs, ankles, knees). We did not notice any significant divergence between uricemia and uraturia of gouty and non gouty people. Within the group of gouty people, percentage of individual hyper excretion is 53% (uraturia greater than 600 mg/24 h) with no significant divergence with the non-gouty group: Nephrolithiasis is rare (3%). There is no significant divergence between urinary pH of gouty and non-gouty people. Associated metabolic troubles are: diabetes (26%) high triglyceridemia (43%) three syndromes associated together (hyperuricemia + diabetes + hypertriglyceridemia) in 19.5%, total cholesterol is normal (2.07 g/l) but a low cholesterol (0.30 g/l).(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

法属波利尼西亚痛风的高发率促使我们从普通内科病房收治的患者群体中定义一种“波利尼西亚高尿酸血症”类型。每位入院患者都会立即接受血液检查。男性血尿酸值高于70mg/l、女性高于60mg/l被视为病理性。在这种情况下,连续三天每天检测血尿酸和尿尿酸,并取这三次检测的平均值。另一方面,一些非高尿酸血症的入院患者也按照相同方案进行检查。这样,我们有两组:31例高尿酸血症患者和20例非高尿酸血症患者,然后根据年龄、性别、种族进行二次分组。我们未考虑高尿酸血症的一些继发原因(慢性肾功能不全、利尿治疗、银屑病等)。1. 在高尿酸血症人群中,平均血尿酸为85.35mg/l,而第二个样本为52.65mg/l。在高尿酸血症组(21名男性和10名女性)中,48%患有痛风,其中13%为女性。关节表现为急性关节炎,主要累及下肢、脚踝、膝盖)。我们未发现痛风患者与非痛风患者在血尿酸和尿尿酸之间有任何显著差异。在痛风患者组中,个体高排泄率为53%(尿尿酸大于600mg/24h),与非痛风组无显著差异:肾结石罕见(3%)。痛风患者与非痛风患者的尿液pH值无显著差异。相关的代谢紊乱有:糖尿病(26%)、高甘油三酯血症(43%)、三种综合征同时存在(高尿酸血症 + 糖尿病 + 高甘油三酯血症)占19.5%,总胆固醇正常(2.07g/l)但低密度脂蛋白胆固醇较低(0.30g/l)(摘要截选至250字)

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