Nan Hairong, Qiao Qing, Dong Yanhu, Gao Weiguo, Tang Bin, Qian Rongli, Tuomilehto Jaakko
Qingdao Diabetes Epidemiology Study Group, Qingdao Endocrine and Diabetes Institute, Qingdao, China.
J Rheumatol. 2006 Jul;33(7):1346-50.
Hyperuricemia and gout have shown an increase worldwide. Data are lacking for the prevalence of hyperuricemia and gout and their correlates in China. We studied the occurrence of these conditions in Chinese adults in the city of Qingdao.
A population-based cross-sectional survey for hyperuricemia and gout was performed among 2438 adults (1535 women, 903 men; aged 20-74 yrs) in 2002. Fasting serum uric acid (UA) and lipid profiles were determined, as well as height, weight, and blood pressure. Hyperuricemia was defined as serum UA levels >or= 420 micromol/l in men and >or= 360 micromol/l in women. Diagnosis of gout was self-reported. Complete biochemical and questionnaire data were available for analysis from 1303 women and 720 men.
The age-standardized prevalence was 25.3% for hyperuricemia and 0.36% for gout in adults aged 20 to 74 years. Hyperuricemia was more prevalent in men than in women (32.1% vs 21.8%; p < 0.001). Age-adjusted mean serum UA level was 389.3 micromol/l in men and 315.7 micromol/l in women. Serum UA increased with age in women only (p for trend < 0.001). Body mass index and serum triglycerides had the strongest associations with serum UA in both genders, followed by alcohol drinking and diastolic blood pressure in men, and systolic blood pressure and total cholesterol in women.
The prevalence of hyperuricemia in the urban adult population in Qingdao city is high, while the frequency of gout is lower. Obesity, hypertension, and dyslipidemia are the major factors associated with hyperuricemia in this study.
全球范围内高尿酸血症和痛风的发病率呈上升趋势。中国缺乏高尿酸血症和痛风的患病率及其相关因素的数据。我们研究了青岛市成年人群中这些疾病的发生情况。
2002年对2438名成年人（1535名女性，903名男性；年龄20 - 74岁）进行了一项基于人群的高尿酸血症和痛风横断面调查。测定了空腹血清尿酸（UA）和血脂谱，以及身高、体重和血压。高尿酸血症定义为男性血清UA水平≥420 μmol/L，女性≥360 μmol/L。痛风诊断通过自我报告。1303名女性和720名男性有完整的生化和问卷调查数据可供分析。
20至74岁成年人中，高尿酸血症的年龄标准化患病率为25.3%，痛风为0.36%。高尿酸血症在男性中比女性更普遍（32.1%对21.8%；p < 0.001）。年龄调整后的男性平均血清UA水平为389.3 μmol/L，女性为315.7 μmol/L。仅在女性中血清UA随年龄增加（趋势p < 0.001）。体重指数和血清甘油三酯与男女血清UA的关联最强，其次是男性的饮酒和舒张压，以及女性的收缩压和总胆固醇。
青岛市城市成年人群中高尿酸血症患病率较高，而痛风发病率较低。肥胖、高血压和血脂异常是本研究中与高尿酸血症相关的主要因素。
