Głowiński S, Worowski K
Cor Vasa. 1979;21(4):296-303.
The distribution and variation of thromboplastic and fibrinolytic activity were studied in various layers of polyester grafts in the dog aorta. One, four and 36 months after implantation, these grafts were removed together with segments of normal arteries and veins and dissected into three layers. The thromboplastic and plasminogen activator activities in these layers were then determined. It was found that in the early post-operative period, the thromboplastic activity in the Dacron graft neointima is very high, whereas that of the plasminogen activator is relatively low. With the passage of time the thromboplastic activity decreases and plasminogen activator activity increases. Similarly the thromboplastic activity in the neomedial and neoadventitial layers of the graft falls as time elapses after the implantation and the fibrinolytic activity gradually increases. These changes in thromboplastic and fibrinolytic activity increase the danger of graft thrombosis in the early post-operative period whereas in the later period they are favourable to maintenance of graft patency.
研究了犬主动脉中聚酯移植物各层的促凝血活性和纤溶活性的分布及变化。植入后1个月、4个月和36个月，将这些移植物与正常动脉和静脉段一起取出，并解剖成三层。然后测定这些层中的促凝血活性和纤溶酶原激活物活性。结果发现，在术后早期，涤纶移植物新生内膜中的促凝血活性非常高，而纤溶酶原激活物的活性相对较低。随着时间的推移，促凝血活性降低，纤溶酶原激活物活性增加。同样，植入后随着时间的推移，移植物新中层和新外膜层中的促凝血活性下降，纤溶活性逐渐增加。促凝血活性和纤溶活性的这些变化在术后早期增加了移植物血栓形成的危险，而在后期则有利于维持移植物通畅。
