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通过肌肉注射链脲佐菌素诱导大鼠患糖尿病。

The induction of diabetes in rats by intramuscular administration of streptozotocin.

作者信息

Nakhoda A, Wong H A

出版信息

Experientia. 1979 Dec 15;35(12):1679-80. doi: 10.1007/BF01953269.

DOI:10.1007/BF01953269
PMID:160326
Abstract

Streptozotocin administered i.m. was as effective a diabetogenic agent as when administered i.v. This is useful, particularly for the induction of diabetes in small animals.

摘要

肌肉注射链脲佐菌素作为一种致糖尿病药物，其效果与静脉注射时相同。这一点很有用，尤其适用于诱导小动物患糖尿病。

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本文引用的文献

1
ABNORMAL GLUCOSE TOLERANCE IN REPEATEDLY BRED RATS WITH ARTERIOSCLEROSIS.患有动脉粥样硬化的多次繁殖大鼠的葡萄糖耐量异常。
Nature. 1963 Oct 12;200:133-6. doi: 10.1038/200133a0.
2
Immunoassay of insulin with insulin-antibody precipitate.用胰岛素 - 抗体沉淀物进行胰岛素免疫测定。
Biochem J. 1963 Jul;88(1):137-46. doi: 10.1042/bj0880137.
3
Studies of the diabetogenic action of streptozotocin.链脲佐菌素致糖尿病作用的研究。
兼具速效和长效降血糖特性的可溶性胰岛素类似物——从高效大肠杆菌表达系统到药物制剂
PLoS One. 2017 Mar 15;12(3):e0172600. doi: 10.1371/journal.pone.0172600. eCollection 2017.
4
Antidiabetic effect of kolaviron, a biflavonoid complex isolated from Garcinia kola seeds, in Wistar rats.可乐维隆（一种从可乐果种子中分离出的双黄酮复合物）对Wistar大鼠的抗糖尿病作用。
Afr Health Sci. 2012 Dec;12(4):498-506. doi: 10.4314/ahs.v12i4.16.
5
Effects of combined neutral endopeptidase 24-11 and angiotensin-converting enzyme inhibition on femoral vascular conductance in streptozotocin-induced diabetic rats.中性内肽酶24-11与血管紧张素转换酶联合抑制对链脲佐菌素诱导的糖尿病大鼠股血管传导的影响。
Br J Pharmacol. 2000 Jul;130(6):1297-304. doi: 10.1038/sj.bjp.0703442.
6
Adenosine effects on glucose oxidation of adipocytes isolated from streptozotocin-diabetic rats.腺苷对从链脲佐菌素诱导的糖尿病大鼠分离的脂肪细胞葡萄糖氧化的影响。
Biochem J. 1985 Nov 15;232(1):301-4. doi: 10.1042/bj2320301.
Proc Soc Exp Biol Med. 1967 Oct;126(1):201-5. doi: 10.3181/00379727-126-32401.
4
Error of intraperitoneal injections in rats.大鼠腹腔注射的误差
Lab Anim Care. 1966 Dec;16(6):505-9.