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Effect of niacin/nicotinamide deficiency on the diabetogenic effect of streptozotocin.

作者信息

Wright J R, Mendola J, Lacy P E

机构信息

Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.

出版信息

Experientia. 1988 Jan 15;44(1):38-40. doi: 10.1007/BF01960237.

DOI:10.1007/BF01960237
PMID:2965027
Abstract

Weanling CD-1 mice were fed either a control diet or a diet deficient in niacin/nicotinamide for one month and then injected i.v. with 60, 80, 100, 120, 140, or 160 mg/kg streptozotocin. Mice on the deficient diet developed a higher incidence of diabetes and more severe hyperglycemia than those on the control diet.

摘要

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Effect of niacin/nicotinamide deficiency on the diabetogenic effect of streptozotocin.
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[Correcting effect of nicotinamide on hemoglobin glycosylation in streptozotocin diabetes in rats].[烟酰胺对链脲佐菌素诱导的糖尿病大鼠血红蛋白糖基化的纠正作用]
Vopr Med Khim. 1995 Jan-Feb;41(1):36-8.
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Adv Exp Med Biol. 1986;206:331-8. doi: 10.1007/978-1-4613-1835-4_24.
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Combined effect of nicotinamide and streptozotocin on diabetic status in partially pancreatectomized adult BALB/c mice.烟酰胺和链脲佐菌素对部分胰腺切除的成年BALB/c小鼠糖尿病状态的联合作用。
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本文引用的文献

1
Significance of streptozotocin induced nicotinamide-adenine-dinucleotide (NAD) degradation in mouse pancreatic islets.链脲佐菌素诱导小鼠胰岛中烟酰胺腺嘌呤二核苷酸（NAD）降解的意义
FEBS Lett. 1973 Mar 1;30(2):225-228. doi: 10.1016/0014-5793(73)80656-8.
2
Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis.超氧化物歧化酶、过氧化氢酶和聚（ADP - 核糖）合成酶抑制剂对四氧嘧啶和链脲佐菌素诱导的胰岛DNA链断裂以及对胰岛素原合成抑制的保护作用。
J Biol Chem. 1982 Jun 10;257(11):6084-8.
3
Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets.
Nature. 1981 Nov 19;294(5838):284-6. doi: 10.1038/294284a0.
4
Effects of streptozotocin on a clonal isolate of rat insulinoma cells.链脲佐菌素对大鼠胰岛素瘤细胞克隆株的影响。
Biochim Biophys Acta. 1984 Aug 17;804(4):387-92. doi: 10.1016/0167-4889(84)90064-8.
5
Drugs producing diabetes through damage of the insulin secreting cells.通过损伤胰岛素分泌细胞而导致糖尿病的药物。
Pharmacol Rev. 1970 Dec;22(4):485-518.
6
Streptozotocin diabetes. Correlation with extent of depression of pancreatic islet nicotinamide adenine dinucleotide.链脲佐菌素糖尿病。与胰岛烟酰胺腺嘌呤二核苷酸抑制程度的相关性。
J Clin Invest. 1974 Sep;54(3):672-7. doi: 10.1172/JCI107805.
7
Streptozotocin diabetes--further studies on the mechanism of depression of nicotinamide adenine dinucleotide concentrations in mouse pancreatic islets and liver.链脲佐菌素糖尿病——关于小鼠胰岛和肝脏中烟酰胺腺嘌呤二核苷酸浓度降低机制的进一步研究。
Biochem Pharmacol. 1973 Oct 15;22(20):2625-31. doi: 10.1016/0006-2952(73)90071-3.
8
Pyridine nucleotide depletion in pancreatic islets associated with streptozotocin-induced diabetes.链脲佐菌素诱导的糖尿病相关的胰岛中吡啶核苷酸耗竭。
Diabetes. 1972 Jul;21(7):789-93. doi: 10.2337/diab.21.7.789.
9
Reversal of streptozotocin diabetes with nicotinamide.烟酰胺逆转链脲佐菌素诱导的糖尿病
Proc Soc Exp Biol Med. 1969 Mar;130(3):992-4. doi: 10.3181/00379727-130-33707.
10
The use of nicotinamide to modify the toxicity of streptozotocin diabetes without loss of antitumor activity.使用烟酰胺改变链脲佐菌素糖尿病的毒性而不丧失抗肿瘤活性。
Cancer Res. 1967 Dec;27(12):2324-32.