神经系统疾病患者脑脊液中的寡克隆免疫球蛋白D

Oligoclonal immunoglobulin D in the cerebrospinal fluid of neurologic patients.

作者信息

Mavra M, Luxton R, Keir G, Thompson E J

机构信息

Department of Special Chemical Pathology, National Hospital for Neurology and Neurosurgery, London, United Kingdom.

出版信息

Neurology. 1992 Jun;42(6):1244-5. doi: 10.1212/wnl.42.6.1244.

DOI:10.1212/wnl.42.6.1244

PMID:1603353

Abstract

Oligoclonal immunoglobulin D (IgD) bands were observed in 20 of 110 CSF samples investigated by our method for isoelectric focusing (IEF) of IgD in unconcentrated CSF. These were mostly from demyelinating disorders, viral CNS infections, and CNS tumors. The patterns of expression of IgD were similar to that of IgG, except in cases with tumors where oligoclonal IgD may occur independently of IgG. The study shows for the first time the presence of oligoclonal IgD in CSF from neurologic patients.

摘要

在我们采用未浓缩脑脊液中IgD等电聚焦（IEF）方法检测的110份脑脊液样本中，有20份观察到寡克隆免疫球蛋白D（IgD）条带。这些样本大多来自脱髓鞘疾病、病毒性中枢神经系统感染和中枢神经系统肿瘤。IgD的表达模式与IgG相似，不过在肿瘤病例中，寡克隆IgD可能独立于IgG出现。该研究首次表明神经系统疾病患者的脑脊液中存在寡克隆IgD。