Kitayama Noriyuki, Vaccarino Viola, Kutner Michael, Weiss Paul, Bremner J Douglas
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA.
J Affect Disord. 2005 Sep;88(1):79-86. doi: 10.1016/j.jad.2005.05.014.
Studies in animals showed that the hippocampus, a brain area involved in learning and memory, is sensitive to stress. Although several MRI studies showed smaller hippocampal volume in adults with chronic PTSD, others did not show significant differences from controls. These studies are typified by small sample sizes which may limit the ability to show significant differences. We therefore performed a meta-analytic study of all of these studies to clarify the role of hippocampal structural changes in subjects with PTSD.
Nine studies with a total of 133 adult subjects with chronic PTSD, 148 healthy controls, and 53 traumatized controls were included in the meta-analysis.
There was significantly smaller volume in both right and left hippocampi in adult subjects with chronic PTSD in comparison with both healthy controls and traumatized controls.
These findings are consistent with smaller hippocampal volume in adult subjects with chronic PTSD.
动物研究表明，海马体作为大脑中参与学习和记忆的区域，对压力敏感。尽管多项MRI研究显示，患有慢性创伤后应激障碍（PTSD）的成年人海马体体积较小，但其他研究并未显示出与对照组有显著差异。这些研究的典型特征是样本量小，这可能会限制显示显著差异的能力。因此，我们对所有这些研究进行了一项荟萃分析，以阐明海马体结构变化在PTSD患者中的作用。
荟萃分析纳入了9项研究，共有133名患有慢性PTSD的成年受试者、148名健康对照者和53名创伤对照者。
与健康对照者和创伤对照者相比，患有慢性PTSD的成年受试者的左右海马体体积均显著较小。
这些发现与患有慢性PTSD的成年受试者海马体体积较小一致。
