Ventura-Bort Carlos, Wirkner Janine, Wendt Julia, Schwabe Lars, Dolcos Florin, Hamm Alfons O, Weymar Mathias
Department of Biological Psychology and Affective Science, Faculty of Human Sciences, University of Potsdam, Potsdam, Germany.
Department of Clinical Psychology and Psychotherapy, Institute of Psychology, University of Greifswald, Greifswald, Germany.
Neurobiol Stress. 2024 Nov 14;33:100691. doi: 10.1016/j.ynstr.2024.100691. eCollection 2024 Nov.
Although the mediating role of the stress hormone systems in memory for single- especially emotional- events is well-stablished, less is known about the influence of stress on memory for associated contextual information (source memory). Here, we investigated the impact of acute stress on the neural underpinnings of emotional contextual source memory. Participants underwent a stress or a control manipulation before they encoded objects paired with pleasant, neutral, or unpleasant backgrounds. One week later, item and contextual source memory were tested. Acute stress modulated the neural signature of item and contextual source memory in an opposite fashion: stressed participants showed larger activation in the precuneus and the medial prefrontal cortex (mPFC) during the retrieval of items, while the retrieval of contextual unpleasant information was associated with lower activation in the angular gyrus (AG) and mPFC. Furthermore, as revealed by cross-region representational similarity analyses, stress also reduced the memory reinstatement of the previously encoded visual cortex representations of object/unpleasant background pairings in the AG and mPFC. These results suggest that pre-encoding stress induction increases the activity of memory-related regions for single items but reduces the activity of these regions during the retrieval of contextual unpleasant information. Our findings provide new insights into the dissociative effects of stress on item and contextual source memory which could have clinical relevance for stress-related disorders.
虽然应激激素系统在对单个事件（尤其是情感事件）的记忆中的中介作用已得到充分证实，但关于应激对相关情境信息（来源记忆）记忆的影响却知之甚少。在此，我们研究了急性应激对情感情境来源记忆神经基础的影响。参与者在对与愉快、中性或不愉快背景配对的物体进行编码之前，接受了应激或对照操作。一周后，对物品和情境来源记忆进行了测试。急性应激以相反的方式调节物品和情境来源记忆的神经特征：应激参与者在物品检索期间在楔前叶和内侧前额叶皮质（mPFC）表现出更大的激活，而情境不愉快信息的检索与角回（AG）和mPFC中较低的激活相关。此外，通过跨区域表征相似性分析表明，应激还减少了AG和mPFC中先前编码的物体/不愉快背景配对的视觉皮质表征的记忆恢复。这些结果表明，编码前应激诱导增加了单个物品记忆相关区域的活动，但在情境不愉快信息检索期间降低了这些区域的活动。我们的研究结果为应激对物品和情境来源记忆的分离效应提供了新的见解，这可能对应激相关障碍具有临床意义。
