Gauthier D W, Meyer W J, Bieniarz A
Department of Obstetrics and Gynecology, University of Illinois College of Medicine, Chicago.
Obstet Gynecol. 1992 Jul;80(1):102-5.
The biophysical profile has been proposed as a noninvasive method of detecting fetal infection in patients with preterm premature rupture of membranes (PROM). The purpose of this study was to evaluate the biophysical profile as a rapid predictor of amniotic fluid (AF) culture results in women with PROM. Amniocentesis was performed on 111 patients with PROM at or before 34 weeks' estimated gestational age. Aerobic, anaerobic, Ureaplasma, and Mycoplasma cultures were performed on the AF. A biophysical profile was performed just before the amniocentesis. Women with positive AF cultures had a significantly lower total biophysical profile score, as well as significantly lower scores for nonstress test, fetal breathing movements, fetal movements, and AF volume, than those with negative AF cultures. However, neither the total biophysical profile score nor any of the individual components had sufficient sensitivity, specificity, or positive or negative predictive value to be useful clinically in predicting culture results. Although the incidence of positive AF cultures was inversely related to the biophysical profile score, 48% of patients with a score of 8 and 27% of those with a score of 10 had positive AF cultures. The results of this study do not support use of the biophysical profile as an early predictor of AF culture results in patients with PROM.
生物物理评分已被提议作为一种检测胎膜早破（PROM）患者胎儿感染的非侵入性方法。本研究的目的是评估生物物理评分作为PROM女性羊水（AF）培养结果的快速预测指标。对111例孕龄估计在34周及以前的PROM患者进行了羊膜腔穿刺术。对羊水进行了需氧菌、厌氧菌、解脲脲原体和支原体培养。在羊膜腔穿刺术之前进行了生物物理评分。与羊水培养阴性的女性相比，羊水培养阳性的女性生物物理评分总分显著更低，无应激试验、胎儿呼吸运动、胎动及羊水体积评分也显著更低。然而，生物物理评分总分及任何单个成分均没有足够的敏感性、特异性、阳性或阴性预测价值，无法在临床上用于预测培养结果。尽管羊水培养阳性的发生率与生物物理评分呈负相关，但评分8分的患者中有48%羊水培养阳性，评分10分的患者中有27%羊水培养阳性。本研究结果不支持将生物物理评分作为PROM患者羊水培养结果的早期预测指标。
