Häkkinen L M, Vuolteenaho O J, Leppäluoto J P, Laatikainen T J
Department of Obstetrics and Gynecology, University of Oulu, Finland.
Obstet Gynecol. 1992 Jul;80(1):72-5.
We measured endothelin-1, a potent vasoconstrictor peptide released by the vascular endothelium, in maternal, umbilical cord, and retroplacental blood plasma in cases of spontaneous and elective cesarean delivery. Mean (+/- standard error) endothelin-1 in the maternal plasma increased with advancing pregnancy, from 1.2 +/- 0.13 pmol/L at 32-34 weeks to 2.4 +/- 0.2 pmol/L at 38-41 weeks (P less than .01) and 3.4 +/- 0.3 pmol/L (P less than .02) during labor. Concentrations were significantly higher in umbilical cord plasma than in maternal venous plasma, and higher in the cord venous plasma after vaginal delivery (52.9 +/- 11.4 pmol/L) than after cesarean performed before the onset of labor (9.0 +/- 1.1 pmol/L) (P less than .001). In spontaneous labor, concentrations in the retroplacental blood plasma (23.3 +/- 4.5 pmol/L) were approximately ten times higher than those in the maternal peripheral blood. Levels in the umbilical cord and retroplacental blood plasma were the highest found so far in any physiologic condition, suggesting that an increased intrauterine release of endothelin-1 at delivery may promote constriction of the blood vessels in the umbilical cord and placental bed.
我们在自然分娩和择期剖宫产病例中，测量了血管内皮释放的一种强力血管收缩肽——内皮素-1在母体、脐带和胎盘后血浆中的含量。母体血浆中内皮素-1的平均（±标准误）含量随孕周增加而升高，从32 - 34周时的1.2±0.13 pmol/L升至38 - 41周时的2.4±0.2 pmol/L（P＜0.01），分娩时为3.4±0.3 pmol/L（P＜0.02）。脐带血浆中的浓度显著高于母体静脉血浆，经阴道分娩后的脐静脉血浆浓度（52.9±11.4 pmol/L）高于临产前剖宫产的脐静脉血浆浓度（9.0±1.1 pmol/L）（P＜0.001）。在自然分娩时，胎盘后血浆中的浓度（23.3±4.5 pmol/L）约为母体外周血浓度的10倍。脐带和胎盘后血浆中的含量是迄今在任何生理状态下所发现的最高值，这表明分娩时子宫内内皮素-1释放增加可能会促进脐带和胎盘床血管的收缩。
