Maeda H, Takeshita J, Kanamaru R, Sato H, Khatoh J, Sato H
Gan. 1979 Oct;70(5):601-6.
A highly lymphotropic derivative of a proteinaceous antitumor agent, Neocarzinostatin, was prepared by chemical conjugation of a water-soluble synthetic poly(maleic acid)-styrene oligomer. The derivative of 2.5 X 10(4) dalton exhibited a strong antitumor activity against AH109A and DBLA-6 as well as antimetastatic activity against metastatic AH109A with which experimental lymphatic metastasis was produced in rats. An increased lipophilicity and molecular weight of the derivative appear to be responsible for its improvement as lymphotropic antimetastatic agent.
通过水溶性合成聚（马来酸）-苯乙烯低聚物的化学偶联制备了一种蛋白质类抗肿瘤剂新制癌菌素的高亲淋巴衍生物。该2.5×10⁴道尔顿的衍生物对AH109A和DBLA-6显示出很强的抗肿瘤活性，以及对在大鼠中产生实验性淋巴转移的转移性AH109A具有抗转移活性。该衍生物亲脂性和分子量的增加似乎是其作为亲淋巴抗转移剂性能改善的原因。
