Anavi Y, Mintz S
Department of Oral and Maxillofacial Surgery, Beilinson Medical Center, Petah Tiqva, Israel.
Pediatr Dermatol. 1992 Jun;9(2):123-5. doi: 10.1111/j.1525-1470.1992.tb01227.x.
A patient had extensive congenital oral hyperpigmentation of the tongue. The clinical and histologic features set this case apart from any well-delineated disease. Clinically, the congenital onset, the appearance of large black-brownish lesions, the lack of associated systemic abnormalities, and the histologic findings of prominent deposition of melanin in the basal layer support the diagnosis of physiologic melanosis. The macular lesions of the tongue represent discrete depositions of melanin and exemplify soft tissue pigmentation of developmental origin.
一名患者患有广泛的先天性舌部口腔色素沉着。该病例的临床和组织学特征使其有别于任何明确界定的疾病。临床上，先天性发病、出现大的黑褐色病变、缺乏相关的全身异常以及基底层黑色素显著沉积的组织学发现支持生理性黑素沉着的诊断。舌部的斑疹性病变代表黑色素的离散沉积，是发育源性软组织色素沉着的例证。
