柳氮磺胺吡啶对活动期溃疡性结肠炎患者活检黏膜病变及组织学分级的影响。

Effects of sulfasalazine on biopsy mucosal pathologies and histological grading of patients with active ulcerative colitis.

作者信息

Zhong Ying-Qiang, Huang Hua-Rong, Zhu Zhao-Hua, Chen Qi-Kui, Zhan Jun, Xing Lian-Chun

机构信息

Department of Gastroenterology, the Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510120, Guangdong Province, China.

出版信息

World J Gastroenterol. 2005 Jul 28;11(28):4435-8. doi: 10.3748/wjg.v11.i28.4435.

DOI:10.3748/wjg.v11.i28.4435

PMID:16038049

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4434677/

Abstract

AIM

To investigate the mechanisms of sulfasalazine (SASP) in the treatment of ulcerative colitis (UC).

METHODS

Changes of pathological signs and histological grading of 106 patients with active UC were observed before and after the treatment with SASP, 1 g, thrice daily for 6 wk.

RESULTS

The effect of SASP on the vasculitis in lamina propria was 48.2% and 17.4% in the mild active UC (P<0.001) and 68% and 26.7% in the moderate active UC (P<0.001) before and after treatment. Fibroid necrosis of vessel wall was found in one case of mild UC and two cases of moderate UC before treatment and was not found after treatment. No thrombosis was found in mild UC before and after treatment, while thrombosis was found in one case of moderate UC before treatment. The effect on mucosal glandular abnormality was 30.4% and 13.0% in mild UC (P<0.05), and 42% and 40% in moderate UC (P>0.05) before and after treatment. The rate of eosinophil infiltration was 98.2% and 80.4% in mild UC (P<0.01), and 100% and 91.1% in moderate UC (P<0.05) before and after treatment. The effect on crypt abscess was 21.4% and 4.4% in mild UC (P<0.05), and 48% and 13.3% in moderate UC (P<0.001) before and after treatment. The effect on mucosal pathohistological grading was 2.00+/-0.84 and 0.91+/-0.46 in mild UC (P<0.001), and 2.49+/-0.84 and 1.31+/-0.75 in moderate UC (P<0.001) before and after treatment.

CONCLUSION

SASP can improve small vessel lesions and crypt abscesses and reduce neutrophilic and eosinophilic leukocyte infiltration in inflammatory mucosa of UC.

摘要

目的

探讨柳氮磺胺吡啶（SASP）治疗溃疡性结肠炎（UC）的机制。

方法

观察106例活动期UC患者在接受SASP治疗（1克，每日3次，共6周）前后的病理体征和组织学分级变化。

结果

SASP对轻度活动期UC固有层血管炎的治疗有效率在治疗前后分别为48.2%和17.4%（P<0.001），对中度活动期UC分别为68%和26.7%（P<0.001）。治疗前，轻度UC中有1例、中度UC中有2例出现血管壁纤维样坏死，治疗后未再发现。轻度UC治疗前后均未发现血栓形成，而中度UC治疗前有1例出现血栓形成。SASP对轻度UC黏膜腺体异常的治疗有效率在治疗前后分别为30.4%和13.0%（P<0.05），对中度UC分别为42%和40%（P>0.05）。轻度UC治疗前后嗜酸性粒细胞浸润率分别为98.2%和80.4%（P<0.01），中度UC分别为100%和91.1%（P<0.05）。SASP对轻度UC隐窝脓肿的治疗有效率在治疗前后分别为21.4%和4.4%（P<0.05），对中度UC分别为48%和13.3%（P<0.001）。SASP对轻度UC黏膜病理组织学分级的影响在治疗前后分别为2.00±0.84和0.91±0.46（P<0.001），对中度UC分别为2.49±0.84和1.31±0.75（P<0.001）。