在溃疡性结肠炎中，中性粒细胞的黏膜浸润伴随着白细胞介素-8在局部的产生增加。
Neutrophil mucosal involvement is accompanied by enhanced local production of interleukin-8 in ulcerative colitis.
作者信息
Raab Y, Gerdin B, Ahlstedt S, Hällgren R
机构信息
Department of Surgery, University Hospital, Uppsala, Sweden.
出版信息
Gut. 1993 Sep;34(9):1203-6. doi: 10.1136/gut.34.9.1203.
Abstract
The concentration of myeloperoxidase, a neutrophil granule constituent, was measured in the perfusion fluid from sigmoid and rectal segments in patients with ulcerative colitis. The concentrations of myeloperoxidase were increased severalfold in the patients with ulcerative colitis compared with healthy controls pointing to an enhanced neutrophil activity. The release of myeloperoxidase correlated to an enhanced local release of the neutrophil activating peptide interleukin-8 (IL-8). Increased values of tumour necrosis factor (TNF-alpha) were also found during intestinal perfusion of the patients and correlated with those of IL-8. The results obtained are compatible with the hypothesis that local mucosal recruitment/activation of neutrophils in ulcerative colitis is mediated by an enhanced IL-8 synthesis. TNF-alpha may be one relevant factor as a stimulus to IL-8 synthesis.
摘要
在溃疡性结肠炎患者的乙状结肠和直肠段灌注液中，对中性粒细胞颗粒成分髓过氧化物酶的浓度进行了测量。与健康对照相比，溃疡性结肠炎患者的髓过氧化物酶浓度增加了数倍，这表明中性粒细胞活性增强。髓过氧化物酶的释放与中性粒细胞激活肽白细胞介素-8（IL-8）的局部释放增强相关。在患者肠道灌注期间还发现肿瘤坏死因子（TNF-α）值升高，且与IL-8值相关。所获得的结果与以下假设相符：溃疡性结肠炎中中性粒细胞的局部黏膜募集/激活是由IL-8合成增强介导的。TNF-α可能是刺激IL-8合成的一个相关因素。
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