新生儿常温及低温体外循环期间中空纤维膜式氧合器膜压降的比较

Comparison of hollow-fiber membrane oxygenators in terms of pressure drop of the membranes during normothermic and hypothermic cardiopulmonary bypass in neonates.

作者信息

Undar Akif, Owens W Richard, McGarry Mary Claire, Surprise Deborah L, Kilpack Vicki D, Mueller Maryann W, McKenzie E Dean, Fraser Charles D

机构信息

Congenital Heart Surgery Service, Texas Children's Hospital, Houston, USA.

出版信息

Perfusion. 2005 May;20(3):135-8. doi: 10.1191/0267659105pf796oa.

DOI:10.1191/0267659105pf796oa

PMID:16038384

Abstract

UNLABELLED

The objective of this study was to investigate the effects of two hollow-fiber membrane oxygenators, the Capiox SX10 and the Lilliput 901, on pressure drop of the membranes during normothermic and hypothermic cardiopulmonary bypass (CPB) in neonates.

METHODS

Twenty-six congenital heart surgery patients (n = 13 in each group) with a mean weight of 3 kg were included in this study. Pressure drops of the membranes, pre- and post-oxygenator extracorporeal circuit pressures (ECC) were recorded during normothermic CPB, hypothermic CPB (20 degrees C) and after rewarming. There were no differences between the groups in mean arterial pressure, pump flow rate, temperature, duration of CPB, crossclamp time or the severity of the surgical repairs.

RESULTS

Pressure drop of the Capiox SX10 oxygenator was significantly lower during normothermic (32 +/- 10 versus 55 +/- 16 mmHg, p < 0.001), hypothermic (38 +/- 15 versus 72 +/- 18 mmHg, p < 0.001) and post-rewarming (42 +/- 13 versus 72 +/- 21 mmHg, p < 0.001) periods compared to the Lilliput oxygenator. In the Capiox group, the pre-oxygenator ECC pressure was also significantly lower during normothermic CPB (142 +/- 27 versus 184 +/- 43 mmHg, p < 0.01), hypothermic CPB (162 +/- 30 versus 199 +/- 38 mmHg, p < 0.01) and after rewarming periods (172 +/- 32 versus 212 +/- 42 mmHg, p < 0.01). Post-oxygenator pressures in the Capiox group were also lower than in the Lilliput group, but results were not statistically significant.

CONCLUSIONS

These results suggest that the Capiox SX10 hollow-fiber membrane oxygenator produced significantly lower membrane pressure drops and pre- and post-oxygenator ECC during normothermic and hypothermic CPB. Thus, blood trauma with the Capiox during extracorporeal circulation may be significantly lower compared to the Lilliput. Further studies, including the level of complements, platelets, neutrophils and cytokines, with these oxygenators are warranted.

摘要

未标注

本研究的目的是调查两种中空纤维膜式氧合器，即Capiox SX10和Lilliput 901，在新生儿常温及低温体外循环（CPB）期间对膜压降的影响。

方法

本研究纳入了26例先天性心脏病手术患者（每组n = 13），平均体重3 kg。记录常温CPB、低温CPB（20℃）及复温后膜的压降、氧合器前及体外循环回路压力（ECC）。两组在平均动脉压、泵流量、温度、CPB持续时间、主动脉阻断时间或手术修复的严重程度方面无差异。

结果

与Lilliput氧合器相比，Capiox SX10氧合器在常温（32±10对55±16 mmHg，p < 0.001）、低温（38±15对72±18 mmHg，p < 0.001）及复温后（42±13对72±21 mmHg，p < 0.001）期间的压降显著更低。在Capiox组，氧合器前ECC压力在常温CPB（142±27对184±43 mmHg，p < 0.01）、低温CPB（162±30对199±38 mmHg，p < 0.01）及复温后（172±32对212±42 mmHg，p < 0.01）期间也显著更低。Capiox组氧合器后的压力也低于Lilliput组，但结果无统计学意义。