来自美登木属植物的羽扇豆烷三萜类化合物。

Lupane triterpenoids from Maytenus species.

作者信息

Núñez Marvin J, Reyes Carolina P, Jiménez Ignacio A, Moujir Laila, Bazzocchi Isabel L

机构信息

Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, and Instituto Canario de Investigación del Cáncer, Avenida Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Spain.

出版信息

J Nat Prod. 2005 Jul;68(7):1018-21. doi: 10.1021/np058016w.

DOI:10.1021/np058016w

PMID:16038541

Abstract

Five new lupane triterpenes (1-5), in addition to 24 known ones, were isolated from Maytenus cuzcoina and M. chiapensis. Their structures were elucidated on the basis of spectroscopic analysis, including homonuclear and heteronuclear correlation NMR (COSY, ROESY, HSQC, and HMBC) experiments. The compounds were assayed for antimicrobial and cytotoxic activities, with 3-epi-betulinic acid and 28,30-dihydroxy-3-oxolup-20(29)-ene showing moderate cytotoxicity.

摘要

除了24种已知的羽扇豆烷三萜外，还从库斯科美登木和恰帕斯美登木中分离出5种新的羽扇豆烷三萜（1-5）。通过光谱分析，包括同核和异核相关核磁共振（COSY、ROESY、HSQC和HMBC）实验阐明了它们的结构。对这些化合物进行了抗菌和细胞毒性活性测定，3-表桦木酸和28,30-二羟基-3-氧代羽扇-20(29)-烯表现出中等细胞毒性。