Kanokmedhakul Somdej, Kanokmedhakul Kwanjai, Prajuabsuk Thirada, Panichajakul Sanha, Panyamee Piyanan, Prabpai Samran, Kongsaeree Palangpon
Department of Chemistry, Taxonomic Research Center, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
J Nat Prod. 2005 Jul;68(7):1047-50. doi: 10.1021/np050064t.
Three new azadirachtin derivatives, named azadirachtins O-Q (1-3), along with the known azadirachtin B (4), azadirachtin L (5), azadirachtin M (6) 11alpha-azadirachtin H (7), 11beta-azadirachtin H (8), and azadirachtol (9) were isolated from seed kernels of Azadirachta excelsa. Their structures were established by spectroscopic techniques, and the structure of 3 was confirmed by X-ray analysis. Compounds 1-7 and 9 exhibited toxicity to the diamondback moth (Plutella xylostella) with an LD50 of 0.75-1.92 microg/g body weight, in 92 h.
从印度苦楝（Azadirachta excelsa）的种仁中分离出三种新的印楝素衍生物，命名为印楝素O-Q（1-3），以及已知的印楝素B（4）、印楝素L（5）、印楝素M（6）、11α-印楝素H（7）、11β-印楝素H（8）和印楝醇（9）。通过光谱技术确定了它们的结构，并通过X射线分析证实了化合物3的结构。化合物1-7和9对小菜蛾（Plutella xylostella）具有毒性，在92小时内的半数致死剂量（LD50）为0.75-1.92微克/克体重。
