高迪查诺内酯A和B，来自高迪查迪纳白酒草的克罗烷二萜。

Gaudichanolides A and B, clerodane diterpenes from Baccharis gaudichaudiana.

作者信息

Hayashi Ken-ichiro, Kanamori Takashi, Yamazoe Atsushi, Yamada Masashi, Nozaki Hiroshi

机构信息

Department of Biochemistry, Okayama University of Science, 1-1 Ridai-cho, Okayama City, 700-0005 Japan.

出版信息

J Nat Prod. 2005 Jul;68(7):1121-4. doi: 10.1021/np050081i.

DOI:10.1021/np050081i

PMID:16038564

Abstract

Two new clerodane diterpenoids, gaudichanolides A (1) and B (2), were isolated from the dried twigs of Baccharis gaudichaudiana, together with 7-oxo-16,19-dihydroxy-3,4-dehydroclerodan-15,20-diacid dilactone, spathulenol, 4,10-aromadendranediol, kobusone, trans-cosanyl ferulate, and defuscin. The structures and relative stereochemistry of 1 and 2 were elucidated by detailed 2D NMR spectroscopic experiments, and the absolute stereochemistry of 1 was determined by X-ray crystallographic analysis.

摘要

从高迪南美酒神菊（Baccharis gaudichaudiana）的干燥嫩枝中分离出两种新的克罗烷二萜类化合物，高迪南美酒神菊内酯A（1）和B（2），以及7-氧代-16,19-二羟基-3,4-脱氢克罗丹-15,20-二酸二内酯、斯巴醇、4,10-芳樟二醇、 kobusone、反式松柏醇阿魏酸酯和去辅肌动蛋白。通过详细的二维核磁共振光谱实验阐明了1和2的结构及相对立体化学，通过X射线晶体学分析确定了1的绝对立体化学。