来自高氏酒神菊地上部分的具有增强神经生长因子活性的克罗烷二萜类化合物和黄酮类化合物。

Clerodane diterpenoids and flavonoids with NGF-potentiating activity from the aerial parts of Baccharis gaudichaudiana.

作者信息

Guo Yuanqiang, Li Yushan, Xu Jing, Li Ning, Yamakuni Tohru, Ohizumi Yasushi

机构信息

Department of Pharmaceutical Sciences, Nankai University, Tianjin, P.R. China.

出版信息

Chem Pharm Bull (Tokyo). 2007 Oct;55(10):1532-4. doi: 10.1248/cpb.55.1532.

DOI:10.1248/cpb.55.1532

PMID:17917302

Abstract

A new clerodane diterpene, 15-hydroxy-16-acetoxy-ent-clerod-3-en-18-oic acid (1), together with three known clerodane diterpenes (2-4) and three known flavones (5-7), were isolated from the aerial parts of Baccharis gaudichaudiana. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2, 3, and 5 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.

摘要

从高迪南美酒神菊的地上部分分离出一种新的克罗烷二萜，15-羟基-16-乙酰氧基-对映-克罗-3-烯-18-酸（1），以及三种已知的克罗烷二萜（2-4）和三种已知的黄酮（5-7）。通过光谱分析确定了它们的结构。化合物2、3和5在PC 12D细胞中表现出增强神经生长因子（NGF）诱导的神经突生长的活性。