Müller Patrick, Beltrami Antonio Paolo, Cesselli Daniela, Pfeiffer Peter, Kazakov Andrey, Böhm Michael
Klinik für Innere Medizin III, Kardiologie, Angiologie and internistische Intensivmedizin, Universität des Saarlandes, Kirrberger Strasse, D-66421 Homburg/Saar, Germany.
J Mol Cell Cardiol. 2005 Aug;39(2):377-87. doi: 10.1016/j.yjmcc.2005.03.001.
New strategies are urgently needed for the treatment of terminal heart-failure. Recently, new therapeutic strategies were developed to induce cardiac regeneration and thereby enhancing myocardial performance by using the patients own cell pool. In the quest for adequate donor cells skeletal myoblasts, bone marrow (BM) derived cells, endothelial progenitor cells (EPCs) and resident cardiac stem cells but also cytokine application were examined. This review critically discusses the recent findings in the field of endogenous adult progenitor cells and proposes new areas for future research.
治疗终末期心力衰竭迫切需要新策略。最近，人们开发了新的治疗策略，通过利用患者自身的细胞库来诱导心脏再生，从而增强心肌功能。在寻找合适的供体细胞过程中，研究了骨骼肌成肌细胞、骨髓来源细胞、内皮祖细胞（EPCs）和心脏驻留干细胞，还研究了细胞因子的应用。本文综述批判性地讨论了内源性成体祖细胞领域的最新研究成果，并提出了未来研究的新方向。
