Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Magna Graecia University of Catanzaro, Viale Europa, 88100 Catanzaro, Italy ; Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80100 Naples, Italy.
Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80100 Naples, Italy.
Stem Cells Int. 2015;2015:434962. doi: 10.1155/2015/434962. Epub 2015 Mar 18.
Evidences have shown the presence of multipotent stem cells (SCs) at sites of arterial aneurysms: they can differentiate into smooth muscle cells (SMCs) and are activated after residing in a quiescent state in the vascular wall. Recent studies have implicated the role of matrix metalloproteinases in the pathogenesis of arterial aneurysms: in fact the increased synthesis of MMPs by arterial SMCs is thought to be a pivotal mechanism in aneurysm formation. The factors and signaling pathways involved in regulating wall resident SC recruitment, survival, proliferation, growth factor production, and differentiation may be also related to selective expression of different MMPs. This review explores the relationship between adult vascular wall resident multipotent vascular SCs, MMPs, and arterial aneurysms.
有证据表明，动脉瘤部位存在多能干细胞（SCs）：它们可以分化为平滑肌细胞（SMCs），并在血管壁中处于静止状态后被激活。最近的研究表明，基质金属蛋白酶（MMPs）在动脉瘤发病机制中起作用：事实上，动脉 SMCs 中 MMPs 的合成增加被认为是动脉瘤形成的关键机制。调节壁驻留 SC 募集、存活、增殖、生长因子产生和分化的因素和信号通路也可能与不同 MMPs 的选择性表达有关。本综述探讨了成年血管壁驻留多能血管 SCs、MMPs 和动脉瘤之间的关系。
