性别偏向性基因表达模式揭示的基因组间冲突

Intergenomic conflict revealed by patterns of sex-biased gene expression.

作者信息

Connallon Tim, Knowles L Lacey

机构信息

Department of Ecology and Evolutionary Biology, Museum of Zoology, University of Michigan, Ann Arbor, MI 48109-1079, USA.

出版信息

Trends Genet. 2005 Sep;21(9):495-9. doi: 10.1016/j.tig.2005.07.006.

DOI:10.1016/j.tig.2005.07.006

PMID:16039005

Abstract

Intergenomic conflict can affect the distribution of genes across eukaryotic genomes. Because the phenotypic optima of males and females often differ, the fitness consequences of newly arisen alleles might not be concordant between the sexes and can be sexually antagonistic--genetic variants favored in one sex are deleterious in the other. In this article, we demonstrate that previously unexplained patterns of sex-biased gene expression in Drosophila melanogaster might have evolved by sexual antagonism, and that the majority of sex-biased expression is due to adaptive changes in males, implying that males experience stronger selection than females.

摘要

基因组间的冲突会影响真核生物基因组中基因的分布。由于雄性和雌性的表型最优值往往不同，新出现的等位基因对适合度的影响在两性之间可能并不一致，并且可能具有性拮抗作用——在一种性别中受到青睐的遗传变异在另一种性别中是有害的。在本文中，我们证明了黑腹果蝇中以前无法解释的性别偏向基因表达模式可能是通过性拮抗进化而来的，并且大多数性别偏向表达是由于雄性的适应性变化，这意味着雄性比雌性经历更强的选择。