Bodnar Richard J, Klein Gad E
Department of Psychology and Neuropsychology Doctoral Sub-Program, Queens College, City University of New York, Flushing, NY 11367, USA.
Peptides. 2005 Dec;26(12):2629-711. doi: 10.1016/j.peptides.2005.06.010. Epub 2005 Jul 21.
This paper is the 27th consecutive installment of the annual review of research concerning the endogenous opioid system, now spanning over 30 years of research. It summarizes papers published during 2004 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior, and the roles of these opioid peptides and receptors in pain and analgesia; stress and social status; tolerance and dependence; learning and memory; eating and drinking; alcohol and drugs of abuse; sexual activity and hormones, pregnancy, development and endocrinology; mental illness and mood; seizures and neurologic disorders; electrical-related activity and neurophysiology; general activity and locomotion; gastrointestinal, renal and hepatic functions; cardiovascular responses; respiration and thermoregulation; and immunological responses.
本文是关于内源性阿片系统研究年度综述的第27期连续刊文，该综述目前涵盖了30多年的研究。它总结了2004年发表的研究阿片肽、阿片受体、阿片激动剂和阿片拮抗剂的分子、药理学和基因操作行为效应的论文。持续涵盖的特定主题包括与行为相关的内源性阿片及其受体的分子生化效应和神经化学定位研究，以及这些阿片肽和受体在疼痛与镇痛、应激与社会地位、耐受性与依赖性、学习与记忆、饮食、酒精与药物滥用、性活动与激素、妊娠、发育与内分泌学、精神疾病与情绪、癫痫与神经系统疾病、电相关活动与神经生理学、一般活动与运动、胃肠、肾脏和肝脏功能、心血管反应、呼吸与体温调节以及免疫反应中的作用。
